GTF3C1 - general transcription factor IIIC subunit 1 Gene

Also Known as TFIIIC; TFIIIC220; TFIIICalpha

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 2975

About GTF3C1

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:27,460,613-27,549,913 (from NCBI)

This gene has 13 transcripts (splice variants) and 216 orthologues. Ubiquitous expression in thyroid (RPKM 19.5), prostate (RPKM 18.6) and 25 other tissues.

Summary

Predicted to contribute to DNA binding activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and transcription initiation from RNA polymerase III promoter. Located in nucleolus and nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Apr 2022]

GTF3C1 Products (2)

mRNA Protein Name
NM_001286242.2 NP_001273171.1 general transcription factor 3C polypeptide 1 isoform 2
NM_001520.4 NP_001511.2 general transcription factor 3C polypeptide 1 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables RNA polymerase III general transcription initiation factor activity IDA
IDA: Inferred from direct assay
17409385 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17409385 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
part of transcription factor TFIIIC complex IDA
IDA: Inferred from direct assay
17409385 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GTF3C1 Protein Structure

B-block_TFIIIC

B-block_TFIIIC: B-block binding subunit of TFIIIC (175 - 249)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2109 a.a.
Protein Preferred Names Protein Names

general transcription factor 3C polypeptide 1

  • TF3C-alpha

GTF3C1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
GTF3C1 Q12789 MAGEA4 Homo sapiens Q1RN33
Y2H Array
25416956
Intra
GTF3C1 Q12789 MAGEA4 Homo sapiens Q1RN33
Y2H Prey Pooling
25416956
Intra
GTF3C1 Q12789 GTF3C2 Homo sapiens Q8WUA4
Anti Tag CoIP
17409385
Intra
GTF3C1 Q12789 CMTM5 Homo sapiens Q96DZ9
Validated Y2H
25416956
Intra
GTF3C1 Q12789 AGTRAP Homo sapiens Q6RW13
Y2H Prey Pooling
25416956
Intra
GTF3C1 Q12789 AGTRAP Homo sapiens Q6RW13
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Esophageal Atresia

  • Tracheoesophageal Fistula

  • Congenital Atresia Of Esophagus

  • Congenital Imperforate Esophagus

  • Imperforate Esophagus

  • Oesophageal Atresia

  • Te Fistula

  • Tef

  • Tracheoesophageal Fistula With Or Without Esophageal Atresia
Cerebellofaciodental Syndrome

  • Cerebellar-Facial-Dental Syndrome

  • CFDS
Esophageal Atresia/Tracheoesophageal Fistula

  • Esophageal Atresia And/Or Tracheoesophageal Fistula

  • Tracheoesophageal Fistula With Or Without Esohageal Atresia

  • Esophageal Atresia / Tracheoesophageal Fistula

  • Ea/Tef

  • Esophageal Atresia With Tracheoesophageal Fistula

  • Esophageal Atresia With Or Without Tracheoesophageal Fistula
Bulbar Polio

  • Poliomyelitis, Bulbar

  • Bulbar Poliomyelitis
Spinal Muscular Atrophy, Distal, Autosomal Recessive, 1

  • Smard1

  • DSMA1

  • Sianrf

  • Dhmn6

  • Spinal Muscular Atrophy With Respiratory Distress 1

  • HMN6

  • Severe Infantile Axonal Neuropathy With Respiratory Failure

  • Autosomal Recessive Distal Spinal Muscular Atrophy 1

  • Diaphragmatic Spinal Muscular Atrophy

  • Spinal Muscular Atrophy With Respiratory Distress Type 1

  • Neuronopathy, Distal Hereditary Motor, Type Vi

  • Hmn Vi

  • Neuronopathy, Severe Infantile Axonal, With Respiratory Failure

  • Distal Spinal Muscular Atrophy 1

  • Autosomal Recessive Spinal Muscular Atrophy With Respiratory Distress

  • Distal Hereditary Motor Neuropathy Type 6

  • Distal-Hmn Type 6

  • Severe Infantile Axonal Neuropathy With Respiratory Failure Type 1

  • Spinal Muscular Atrophy, Diaphragmatic

  • Distal Hereditary Motor Neuronopathy Type Vi

  • Distal Spinal Muscular Atrophy Type 1

  • Hmnvi

  • Spinal Muscular Atrophy With Respiratory Distress

  • Autosomal Recessive Distal Spinal Muscular Atrophy Type 1

  • Neuronopathy, Distal Hereditary Motor, 6

  • Dhmn Vi

  • Distal Hereditary Motor Neuropathy Type Vi

  • Severe Infantile Axonal Neuronopathy With Respiratory Failure

  • Spinal Muscular Atrophy Distal Autosomal Recessive 1

  • Atrophy, Muscular, Spinal, Distal, Type 1
Autosomal Recessive Distal Hereditary Motor Neuronopathy

  • Autosomal Recessive Distal Spinal Muscular Atrophy
Breast Squamous Cell Carcinoma

  • Breast Primary Squamous Cell Carcinoma

  • Primary Squamous Cell Carcinoma Of Breast

  • Primary Squamous Cell Carcinoma Of The Breast

  • Scc Of Breast

  • Squamous Cell Carcinoma Of Breast

  • Squamous Cell Breast Carcinoma
Hypomyelinating Leukodystrophy

  • Hld

  • Leukodystrophy, Hypomyelinating
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS05906 GTF3C1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus GTF3C1 MGD MGI:107887
Bos taurus GTF3C1 VGNC VGNC:29702
Rattus norvegicus GTF3C1 RGD RGD:621048
Felis catus GTF3C1 VGNC VGNC:67503
Canis familiaris GTF3C1 VGNC VGNC:41551
Macaca mulatta GTF3C1 VGNC VGNC:73316
Others GTF3C1 NCBI