LIN7C - lin-7 homolog C, crumbs cell polarity complex component Gene
Also Known as MALS3; VELI3; LIN-7C; MALS-3; LIN-7-C
生物種: Homo sapiens
About LIN7C
This gene has 2 transcripts (splice variants), 213 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 9.8), liver (RPKM 7.0) and 25 other tissues.
Summary
Enables L27 domain binding activity and cytoskeletal protein binding activity. Involved in morphogenesis of an epithelial sheet. Located in cell-cell junction; cytoplasm; and plasma membrane. Part of MPP7-DLG1-LIN7 complex. [provided by Alliance of Genome Resources, Apr 2022]
LIN7C Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_018362.4 | NP_060832.1 | protein lin-7 homolog C |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables L27 domain binding |
IDA
IDA: Inferred from direct assay
|
20702775 | GOA |
| enables cytoskeletal protein binding |
IPI
IPI: Inferred from physical interaction
|
17987659 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
21849460 | GOA |
| enables protein domain specific binding |
IPI
IPI: Inferred from physical interaction
|
17237226 | GOA |
| Biological Process GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| involved in morphogenesis of an epithelial sheet |
IMP
IMP: Inferred from mutant phenotype
|
23201090 | GOA |
| Cellular Component GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| part of MPP7-DLG1-LIN7 complex |
IDA
IDA: Inferred from direct assay
|
20702775 | GOA |
| located in cell-cell junction |
IDA
IDA: Inferred from direct assay
|
23201090 | GOA |
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
23201090 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
21849460 | GOA |
LIN7C Protein Structure
L27: L27 domain (14 - 68)
PDZ: PDZ domain (Also known as DHR or GLGF) (94 - 172)
- 0
- 100
- 197 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
protein lin-7 homolog C |
|
LIN7C Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
LIN7C | Q9NUP9 | MPP2 | Homo sapiens | Q14168-4 | 32296183 | |
|
Intra
|
LIN7C | Q9NUP9 | MPP2 | Homo sapiens | Q14168-4 | 32296183 | |
|
Intra
|
LIN7C | Q9NUP9 | MPP7 | Homo sapiens | Q5T2T1 | 32296183 | |
|
Intra
|
LIN7C | Q9NUP9 | MPP7 | Homo sapiens | Q5T2T1 | 32296183 | |
|
Intra
|
LIN7C | Q9NUP9 | MPP7 | Homo sapiens | Q5T2T1 | 33961781 | |
|
Intra
|
LIN7C | Q9NUP9 | MPP7 | Homo sapiens | Q5T2T1 | 28514442 | |
|
Intra
|
LIN7C | Q9NUP9 | PALS2 | Homo sapiens | Q9NZW5 | 32296183 | |
|
Intra
|
LIN7C | Q9NUP9 | PALS2 | Homo sapiens | Q9NZW5 | 32296183 | |
|
Intra
|
LIN7C | Q9NUP9 | PALS2 | Homo sapiens | Q9NZW5 | 32296183 | |
|
Intra
|
LIN7C | Q9NUP9 | PALS2 | Homo sapiens | Q9NZW5 | 33961781 | |
|
Intra
|
LIN7C | Q9NUP9 | PALS2 | Homo sapiens | Q9NZW5 | 28514442 | |
|
Intra
|
LIN7C | Q9NUP9 | MPP3 | Homo sapiens | Q13368 | 33961781 | |
|
Intra
|
LIN7C | Q9NUP9 | MPP3 | Homo sapiens | Q13368 | 32296183 | |
|
Intra
|
LIN7C | Q9NUP9 | MPP3 | Homo sapiens | Q13368 | 28514442 | |
|
Intra
|
LIN7C | Q9NUP9 | MPP3 | Homo sapiens | Q13368 | 32296183 |
関連疾患
| Diseases | Alias | |
|---|---|---|
| Attention Deficit-Hyperactivity Disorder |
|
|
| Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome |
|
|
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Felis catus | LIN7C | VGNC | VGNC:82034 |
| Macaca mulatta | LIN7C | VGNC | VGNC:74070 |
| Mus musculus | LIN7C | MGD | MGI:1330839 |
| Rattus norvegicus | LIN7C | RGD | RGD:621164 |
| Bos taurus | LIN7C | VGNC | VGNC:30897 |
| Others | LIN7C | NCBI |