Lobaric acid
Based on 1 Customer Validation
Lobaric acid is a depsipeptide metabolite isolated from Stereocaulon lichen with antioxidant, antiproliferative, antiviral and enzyme inhibitory activities. Lobaric acid scavenges superoxide free radicals (IC50=97.9 μM) and inhibits cancer cell proliferation (EC50 of 15.2-63.9 μg/mL against leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic and lung cancer cell lines). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50=0.87 μM for human recombinant enzyme) and 12(S)-HETE produced by 12(S)-lipoxygenase (IC50=28.5 μM). Lobaric acid (250 μM) also reduced pathological changes in tobacco leaves infected with tobacco mosaic virus (TMV).
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- 純度: 95.2%
- CAS 番号: 522-53-2
- 分子式: C25H28O8
- 分子量:456.49
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BXPC-3 | EC50 |
1.6 μM
Compound: 4
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Cytotoxicity against human BxPC3 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human BxPC3 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
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[PMID: 27300079] |
| HCT-116 | EC50 |
0.8 μM
Compound: 4
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Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
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[PMID: 27300079] |
| HT-29 | EC50 |
2.39 μM
Compound: Lobaric acid
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Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay
Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay
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[PMID: 24900447] |
| HT-29 | IC50 |
4.54 μM
Compound: Lobaric acid
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Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins
Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins
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[PMID: 24900447] |
| J82 | EC50 |
3.6 μM
Compound: 4
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Cytotoxicity against human J82 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human J82 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
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[PMID: 27300079] |
| K562 | EC50 |
1.4 μM
Compound: 4
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Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
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[PMID: 27300079] |
| U2OS | EC50 |
17.6 μM
Compound: Lobaric acid
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Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay
Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay
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[PMID: 24900447] |
| UMUC3 | EC50 |
3.7 μM
Compound: 4
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Cytotoxicity against human UM-UC-3 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Cytotoxicity against human UM-UC-3 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
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[PMID: 27300079] |
化学情報
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CAS 番号 522-53-2
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性状 Solid
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分子量 456.49
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分子式 C25H28O8
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Color White to off-white
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SMILES
O=C(C1=C(O)C=C(C(OC2=CC(OC)=CC(C(CCCC)=O)=C23)=C1CCCCC)OC3=O)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Lobaric acid 関連分類
HY-117085 関連分類
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