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製品番号: HY-126758

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Ludartin

Ludartin a sesquiterpene lactone, which can be isolated from the plant Artemisia carruthii Wood. Ludartin reduces the expression of myeloperoxidase and malondialdehyde, enhances the expression of glutathione and superoxide dismutase in spinal cord tissue. Ludartin inhibits neuronal apoptosis. Ludartin inhibits the upregulation of tumor necrosis factor-α, interleukin-1β, and interleukin-6. Ludartin improves the motor function of rats with spinal cord injury.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 36149-87-8
分子式: C₁₅H₁₈O₃
分子量:246.30

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Ludartin 構造式

CAS 番号: 36149-87-8

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Glutathione Peroxidase アイソフォーム固有の製品をすべて表示 :

GPX1
GPX4

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	19 μM Compound: Ludartin	Cytotoxicity against human A431 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human A431 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31784199]
A549	IC₅₀	25.18 μM Compound: Ludartin	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31784199]
A549	IC₅₀	7.4 μM Compound: 1	Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay	[PMID: 23886685]
A549	IC₅₀	7.4 μM Compound: 1	Cytotoxicity against human A549 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay Cytotoxicity against human A549 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay	[PMID: 24484897]
B16-F10	IC₅₀	6.6 μM Compound: Ludartin	Cytotoxicity against mouse B16F10 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against mouse B16F10 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31784199]
BHY	IC₅₀	25.18 μM Compound: Ludartin	Antiproliferative activity against human BHY cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human BHY cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31784199]
COLO 205	IC₅₀	25.18 μM Compound: Ludartin	Antiproliferative activity against human COLO205 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human COLO205 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31784199]
HCT-116	IC₅₀	6.9 μM Compound: 1	Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay	[PMID: 23886685]
HCT-116	IC₅₀	6.9 μM Compound: 1	Cytotoxicity against human HCT116 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay Cytotoxicity against human HCT116 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay	[PMID: 24484897]
MCF7	IC₅₀	0.5 μM Compound: 1	Cytotoxicity against human MCF7 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay Cytotoxicity against human MCF7 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay	[PMID: 24484897]
MCF7	IC₅₀	25.18 μM Compound: Ludartin	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31784199]
MIA PaCa-2	IC₅₀	25.18 μM Compound: Ludartin	Antiproliferative activity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31784199]
PC-3	IC₅₀	7.5 μM Compound: 1	Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay	[PMID: 23886685]
PC-3	IC₅₀	7.5 μM Compound: 1	Cytotoxicity against human PC3 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay Cytotoxicity against human PC3 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay	[PMID: 24484897]
T98G	IC₅₀	6.3 μM Compound: 1	Cytotoxicity against human T98G cells assessed as growth inhibition by colorimetric sulphorhodamine B assay Cytotoxicity against human T98G cells assessed as growth inhibition by colorimetric sulphorhodamine B assay	[PMID: 24484897]
THP-1	IC₅₀	3.1 μM Compound: 1	Cytotoxicity against human THP1 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay Cytotoxicity against human THP1 cells assessed as cell growth inhibition after 48 hrs by sulphorhodamine B assay	[PMID: 23886685]
THP-1	IC₅₀	3.1 μM Compound: 1	Cytotoxicity against human THP1 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay Cytotoxicity against human THP1 cells assessed as growth inhibition by colorimetric sulphorhodamine B assay	[PMID: 24484897]

化学情報

CAS 番号 36149-87-8
分子量 246.30
分子式 C₁₅H₁₈O₃
SMILES

C[C@]12[C@]3([H])[C@]4([H])[C@](CCC(C)=C3C[C@@]1([H])O2)([H])C(C(O4)=O)=C
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (274 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Xu Wei, et al., Ludartin exhibits therapeutic effect on spinal cord injury through inhibition of apoptosis and inflammation[J]. 2019.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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生物活性
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純度とドキュメンテーション
参考文献

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Ludartin

Glutathione Peroxidase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Ludartin 関連分類

HY-126758 関連分類