Lysyllysine
Lysyllysine (L-Lysyl-L-lysine ) is an orally active PepT1 substrate. Lysyllysine enhances whole-body protein synthesis, improves intestinal structure, alleviates intestinal mucosal inflammation, and exhibits higher lysine bioavailability in neonatal piglets with PN-induced intestinal atrophy. Lysyllysine inhibits the growth of axenic cyanobacterial strains and induces their cell lysis. Lysyllysine can be used in studies related to intestinal atrophy and metabolism.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 13184-13-9
- 分子式: C12H26N4O3
- 分子量:274.36
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK | IC50 |
10.9 mM
Compound: 48
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Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
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[PMID: 16759105] |
体外実験
Lysyllysine blocks growth and induces cell lysis in axenic cultures of Microcystis novacekii TAC 20-1 and Microcystis viridis NIES 102, with lower inhibitory activity than L-lysine monomer[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Yucatan miniature piglets (male, 7-8 days old, initial body weight 1.69 kg)[1]
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Dosage:0.50 g/kg/d
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Administration:enteral; continuous; 18 hours
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Result:Attained superior intestinal morphological indicators including jejunal mucosa weight 71 mg/cm, villus height 279 μm and small intestinal length 251 cm/kg body weight compared with the other two groups.
Achieved elevated whole-body protein synthesis (28 g/kg/day) and jejunal mucosal free lysine level (0.26 μmol/g tissue), outperforming free lysine and dipeptide combination groups.
Reduced jejunal mucosal myeloperoxidase activity significantly relative to the two control groups.
Upregulated occludin (relative expression = 2.8) and PepT1 (relative expression = 0.75) protein levels, with occludin higher than both reference groups and PepT1 higher than free lysine group only.
Boosted protein synthesis rates in liver, jejunal mucosa, gastrocnemius and longissimus dorsi muscle versus dipeptide combination group, showing no statistical difference from free lysine group.
化学情報
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CAS 番号 13184-13-9
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分子量 274.36
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分子式 C12H26N4O3
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SMILES
NCCCC[C@H](NC([C@@H](N)CCCCN)=O)C(O)=O
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別名
L-Lysyl-L-lysine
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Lysyllysine 関連分類
HY-120791 関連分類
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Keywords
- Lysyllysine
- 13184-13-9
- L-Lysyl-L-lysine
- Amino Acid Derivatives
- whole-body protein synthesis
- intestinal structure
- neonatal piglets
- axenic cyanobacterial strains
- PepT1
- lysine bioavailability
- PN-induced intestinal atrophy
- Microcystis viridis NIES 102
- intestinal mucosal inflammation
- Microcystis novacekii TAC 20-1
- Inhibitor
- inhibitor
- inhibit