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製品番号: HY-129424

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Mezolidon

Name: Mezolidon
Brand: MedChemExpress
SKU: HY-129424
Availability: PreOrder

(別名: KM-1146)

Mezolidon (KM-1146) is an anti-ulcer agent with weak gastric acid secretion inhibitory activity. Mezolidon prevents the formation of gastric mucosal ulcers in stressed rats, increases and maintains their gastric mucosal blood flow, and inhibits the decrease in their transmucosal potential difference. Mezolidon can be used in the research of gastric ulcers.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 82697-73-2
分子式: C₁₂H₁₅NO₃S
分子量:253.32

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Mezolidon 構造式

CAS 番号: 82697-73-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体内実験

Mezolidon (300 mg/kg; i.p.; single dose; 30 minutes before water-immersion stress initiation) significantly prevents gastric ulcer development in water-immersion restraint stress-exposed rats, with efficacy linked to increased and maintained gastric mucosal blood flow and suppressed reductions in gastric mucosal potential difference, while having no effect on gastroduodenal surface pH or blood viscosity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male, 160-180 g, gastric ulcer induced by 3-hour water-immersion restraint stress in urethane-anesthetized rats)^[1]
Dosage:

300 mg/kg
Administration:

i.p.; single dose; 30 minutes before water-immersion stress initiation
Result:

Reduced the total length of gastric ulcers to 3.67 mm relative to the control group.
Elevated gastric mucosal blood flow to 119.8% of baseline at 20 min post-stress and 119.2% of baseline at 30 min post-stress, and sustained mucosal blood flow at 66.6% of baseline at 180 min post-stress, both superior to the control group.
Inhibited the decline of gastric mucosal potential difference (PD) at 120 and 180 min post-stress, retaining PD at higher levels than the control group.
Exerted no obvious influence on gastroduodenal mucosal surface pH or water-immersion stress-triggered elevation of blood viscosity.

化学情報

CAS 番号 82697-73-2
分子量 253.32
分子式 C₁₂H₁₅NO₃S
SMILES

O=C1NC(C2=CC=C(OC)C(OC)=C2)SC1C
別名

KM-1146
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ashida Y, et al. [Anti-ulcer mechanism of mezolidon on water-immersion stress induced gastric ulcers in rats]. Nihon Yakurigaku Zasshi. 1988 Mar;91(3):121-7. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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