N2W2
N2W2 is a tryptophan- and lysine-rich β-hairpin antimicrobial peptide. N2W2 exhibits potent antimicrobial activity but also high toxicity. N2W2 is highly susceptible to trypsin or chymotrypsin. N2W2 can be used for the research of bacterial infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C90H111N21O10
- 分子量:1646.98
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
N2W2 (2-256 μM; 18 h) exhibits potent antimicrobial activity against S. aureus ATCC 25923, E. faecalis ATCC 29212, S. epidermidis ATCC 12228, K. pneumoniae ATCC 700603, E. coli ATCC 25922, and P. aeruginosa ATCC 27853 with a geometric mean of the MIC of 6.3 μM[1].
N2W2 (16-2048 μM; 1 h) exhibits high hemolytic activity against Kunming mouse blood cells with an MHC of 70.8 μM[1].
N2W2 (1 h) exhibits significant cytotoxicity against NRK-52E and GES-1 cells with CC50 values of 10.1 μM and 4.3 μM, respectively[1].
N2W2 is highly susceptible to trypsin or
chymotrypsin and nearly lost their antimicrobial activity after incubation with trypsin or chymotrypsin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 1646.98
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分子式 C90H111N21O10
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配列
Trp-Lys-Trp-Lys-Trp-Trp-Lys-Trp-Lys-Trp-NH2
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シーケンスの短縮
WKWKWWKWKW-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
N2W2 関連分類
HY-P11583 関連分類
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