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製品番号: HY-N12104

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Trichodimerol

(別名: BMS-182123)

Trichodimerol (BMS-182123) is a TNF-α promoter inhibitor that inhibits the activity of lipopolysaccharide-induced cytokine secretion. Trichodimerol inhibits lipopolysaccharide-induced TNF-α promoter activity, reduces steady-state TNF-α mRNA expression, and does not alter the stability of TNF-α mRNA. Trichodimerol inhibits lipopolysaccharide-induced TNF-α secretion in murine and human immune cells. Trichodimerol reduces lipopolysaccharide-induced IL-1β secretion by 25%-50% in vitro. Trichodimerol does not alter total protein synthesis or constitutive lysozyme secretion at effective concentrations. Trichodimerol can be used for the research of septic shock.

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CAS 番号: 145174-90-9
分子式: C₂₈H₃₂O₈
分子量:496.55

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Trichodimerol 構造式

CAS 番号: 145174-90-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

TNF Receptor アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	IC₅₀	28.5 μM Compound: 16	Cytotoxicity against human Jurkat cells after 24 hrs by MTT assay Cytotoxicity against human Jurkat cells after 24 hrs by MTT assay	[PMID: 21146414]
K562	IC₅₀	47.8 μM Compound: 16	Inhibition of NF-kappaB activity in TNFalpha-stimulated human K562 cells after 24 hrs by luciferase reporter gene assay Inhibition of NF-kappaB activity in TNFalpha-stimulated human K562 cells after 24 hrs by luciferase reporter gene assay	[PMID: 21146414]
K562	IC₅₀	74.4 μM Compound: 16	Cytotoxicity against human K562 cells after 24 hrs by MTT assay Cytotoxicity against human K562 cells after 24 hrs by MTT assay	[PMID: 21146414]
U-937	IC₅₀	16.5 μM Compound: 16	Cytotoxicity against human U937 cells after 24 hrs by MTT assay Cytotoxicity against human U937 cells after 24 hrs by MTT assay	[PMID: 21146414]

体外実験

Trichodimerol (BMS-182123) (concentrations leading to >99% inhibition; ~20 h) concentration-dependently inhibits LPS-induced TNF-α production in murine RAW 264.7 macrophages with an IC₅₀ of 600 ng/mL^[1].
Trichodimerol (BMS-182123) (0.1-4.0 μg/mL; 2 h) concentration-dependently inhibits LPS-induced TNF-α production in human peripheral blood monocytes with an IC₅₀ of 4.0 μg/mL^[1].
Trichodimerol (BMS-182123) (concentrations leading to full inhibition; 18-20 h) concentration-dependently inhibits LPS-induced human TNF-α promoter activity in transfected murine RAW macrophages with an IC₅₀ of 200 ng/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

Murine macrophages
Concentration:

2 μg/mL
Incubation Time:

4 h
Result:

Significantly reduced LPS-induced steady-state TNF-α mRNA expression in murine macrophages without altering mRNA stability.

化学情報

CAS 番号 145174-90-9
分子量 496.55
分子式 C₂₈H₃₂O₈
SMILES

C[C@@]12[C@@]3([H])[C@]4([C@@](O1)([C@]5(O[C@@]2([C@@](C(O)=C3C(/C=C/C=C/C)=O)([C@@]5([H])C(C(/C=C/C=C/C)=O)=C4O)C)O)C)O)C
別名

BMS-182123
Structure Classification
- Others
Initial Source
- Endogenous metabolite
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Warr GA, et al. BMS-182123, a fungal metabolite that inhibits the production of TNF-alpha by macrophages and monocytes. J Antibiot (Tokyo). 1996;49(3):234-240. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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生物活性
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Trichodimerol

TNF Receptor アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Trichodimerol 関連分類

HY-N12104 関連分類