XR11576
XR11576 (MLN576) is an orally active inhibitor of topoisomerase I and II. XR11576 shows cytotoxicity against human and murine tumor cell lines (IC50: 6-47 nM).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 346689-77-8
- 分子式: C23H24N4O2
- 分子量:388.46
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Topoisomerase アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COR-L23 | IC50 |
10.1 nM
Compound: XR-11576
|
Cytotoxicity measured using the COR-L23 parental (COR-L23/P) human non small cell lung carcinoma cell line
Cytotoxicity measured using the COR-L23 parental (COR-L23/P) human non small cell lung carcinoma cell line
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[PMID: 11806724] |
| COR-L23 | IC50 |
12.1 nM
Compound: XR-11576
|
Cytotoxicity measured with the drug resistant human non small cell lung carcinoma cell line COR-L23 (COR-L23/R) which over expresses multidrug resistance associated with protein(MRP)
Cytotoxicity measured with the drug resistant human non small cell lung carcinoma cell line COR-L23 (COR-L23/R) which over expresses multidrug resistance associated with protein(MRP)
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[PMID: 11806724] |
| NCI-H69 | IC50 |
1.2 nM
Compound: 11
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Inhibitory activity against drug resistant H69/LX4 line overexpressing P-glycoprotein
Inhibitory activity against drug resistant H69/LX4 line overexpressing P-glycoprotein
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[PMID: 11806725] |
| NCI-H69 | IC50 |
23 nM
Compound: XR-11576
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Cytotoxicity measured using the H69 parental (H69/P) human small cell lung carcinoma cell line
Cytotoxicity measured using the H69 parental (H69/P) human small cell lung carcinoma cell line
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[PMID: 11806724] |
| NCI-H69 | IC50 |
23 nM
Compound: 11
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Inhibitory activity against parental human small cell lung carcinoma cell line (H69P)
Inhibitory activity against parental human small cell lung carcinoma cell line (H69P)
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[PMID: 11806725] |
| NCI-H69 | IC50 |
29 nM
Compound: XR-11576
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Cytotoxicity measured using the drug resistant, P-glycoprotein (Pgp) expressing human small cell lung carcinoma cell line H69/LX4
Cytotoxicity measured using the drug resistant, P-glycoprotein (Pgp) expressing human small cell lung carcinoma cell line H69/LX4
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[PMID: 11806724] |
| P388 | IC50 |
10 nM
Compound: 11
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Inhibitory activity against murine P388 leukemia (P388) cells.
Inhibitory activity against murine P388 leukemia (P388) cells.
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[PMID: 11806725] |
化学情報
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CAS 番号 346689-77-8
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分子量 388.46
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分子式 C23H24N4O2
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SMILES
O=C(N[C@@H](CN(C)C)C)C1=C2C(N=C3C=CC4=C(C=CC=C4C3=N2)OC)=CC=C1
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別名
MLN576
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Di Nicolantonio F, et al. Ex vivo characterization of XR11576 (MLN576) against ovarian cancer and other solid tumors. Anticancer Drugs. 2004 Oct;15(9):849-60. [Content Brief]
[2]. Mistry P, et al. In vitro and in vivo characterization of XR11576, a novel, orally active, dual inhibitor of topoisomerase I and II. Anticancer Drugs. 2002 Jan;13(1):15-28. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
XR11576 関連分類
HY-123143 関連分類
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