2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Kir4.1-IN-1

Kir4.1-IN-1 (Compound 37) is a potent, selective, blood-brain barrier permeable Kir4.1 inhibitor with an IC50 of 0.19 μM. Kir4.1-IN-1 exhibits rapid-onset antidepressant effects.

For research use only. We do not sell to patients.

Kir4.1-IN-1

Kir4.1-IN-1 Chemical Structure

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Kir4.1-IN-1 Related Antibodies

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Description

Kir4.1-IN-1 (Compound 37) is a potent, selective, blood-brain barrier permeable Kir4.1 inhibitor with an IC50 of 0.19 μM. Kir4.1-IN-1 exhibits rapid-onset antidepressant effects[1].

IC50 & Target[1]

Kir4.1

0.19 μM (IC50)

Molecular Weight

417.57

Formula

C24H27N5S
Appearance

Solid

SMILES

C1(NCCCN2CCCCC2)=NC=CC(NC3=CC4=C(SC5=C4C=CC=C5)C=C3)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (119.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3948 mL 11.9740 mL 23.9481 mL
5 mM 0.4790 mL 2.3948 mL 4.7896 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3948 mL 11.9740 mL 23.9481 mL 59.8702 mL
5 mM 0.4790 mL 2.3948 mL 4.7896 mL 11.9740 mL
10 mM 0.2395 mL 1.1974 mL 2.3948 mL 5.9870 mL
15 mM 0.1597 mL 0.7983 mL 1.5965 mL 3.9913 mL
20 mM 0.1197 mL 0.5987 mL 1.1974 mL 2.9935 mL
25 mM 0.0958 mL 0.4790 mL 0.9579 mL 2.3948 mL
30 mM 0.0798 mL 0.3991 mL 0.7983 mL 1.9957 mL
40 mM 0.0599 mL 0.2994 mL 0.5987 mL 1.4968 mL
50 mM 0.0479 mL 0.2395 mL 0.4790 mL 1.1974 mL
60 mM 0.0399 mL 0.1996 mL 0.3991 mL 0.9978 mL
80 mM 0.0299 mL 0.1497 mL 0.2994 mL 0.7484 mL
100 mM 0.0239 mL 0.1197 mL 0.2395 mL 0.5987 mL
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Kir4.1-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kir4.1-IN-1Potassium ChannelKcsAantidepressantmiceInhibitorinhibitorinhibit

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