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Cat. No.: HY-179703

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FXR agonist 15

FXR agonist 15 is a selective, potent and orally active farnesoid X receptor (FXR) agonist with EC₅₀ of 0.76 μM. FXR agonist 15 exhibits no obvious activation on other nuclear receptors including LXRα/β, PXR, PPARα/β/γ, THR-β, with EC₅₀ values all >10 μM. FXR agonist 15 can alleviate steatosis, lobular inflammation, hepatocyte ballooning and liver fibrosis. FXR agonist 15 can be used for the research of nonalcoholic steatohepatitis (NASH).

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CAS No.: 2991276-14-1
화학식: C₂₄H₂₂Cl₂FNO₅S
분자량:526.40

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

FXR agonist 15 Chemical Structure

CAS No.: 2991276-14-1

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

In Vivo

FXR agonist 15 (Compound 19) (20 mg/kg, i.g., per day for 4 weeks) alleviates NASH by reducing liver steatosis, inflammation, and fibrosis in WD + CCl₄ (HY-Y0298)-induced mice NASH models^[1].
FXR agonist 15 (500 mg/kg, p.o., once daily for 10 days) causes no mouse death or abnormal behavior, shows no significant abnormalities in serum liver and kidney function indices (AST, ALT, ALP, creatinine, urea) and blood lipid indices (TG, TC), exhibits no acute toxic damage to major organs, and has good safety in ICR mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

WD + CCl₄-induced mice NASH models (C57BL/6, 8 weeks)^[1]
Dosage:

20 mg/kg
Administration:

Orally gavage, per day for 4 weeks
Result:

Reduced hepatic lipid droplets, NAFLD activity score (NAS), and levels of triacylglycerol (TG) and total cholesterol (TC).
Decreased fibrotic markers (α-SMA, hydroxyproline) and activated the FXR pathway.
Upregulated SHP, BSEP, and OSTβ, while downregulated CYP7A1.

Chemical Information

CAS No. 2991276-14-1
분자량 526.40
화학식 C₂₄H₂₂Cl₂FNO₅S
SMILES

FC1=CC(C2=CC=C(N(S(=O)(C3=C(Cl)C=CC=C3Cl)=O)CC(C)C)C=C2)=CC=C1OCC(O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang W, et al. Design, synthesis, and biological studies of novel sulfonamide derivatives as farnesoid X receptor agonists. Eur J Med Chem. 2023;258:115614. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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