Shc1 - src homology 2 domain-containing transforming protein C1 Gene

Also Known as Shc; p66; ShcA; p66shc

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20416

Summary

Enables epidermal growth factor binding activity; identical protein binding activity; and signaling receptor binding activity. Acts upstream of or within several processes, including actin Cytoskeleton reorganization; circulatory system development; and positive regulation of MAPK cascade. Predicted to be located in endosome membrane and nucleus. Predicted to be part of Shc-EGFR complex. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; heart; liver; skeleton; and skin. Orthologous to human SHC1 (SHC adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Shc1 Products (2)

mRNA	Protein	Name
NM_001113331.2	NP_001106802.1	SHC-transforming protein 1 isoform a
NM_011368.5	NP_035498.2	SHC-transforming protein 1 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables ephrin receptor binding	IPI IPI: Inferred from physical interaction	12925710	MGI
enables epidermal growth factor binding	IPI IPI: Inferred from physical interaction	15467833	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	18413607	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7529871	MGI
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	12367511	MGI
enables transmembrane receptor protein tyrosine kinase adaptor activity	IDA IDA: Inferred from direct assay	7799946	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	10809671	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	10809671	MGI
acts upstream of or within cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	10809671	MGI
acts upstream of or within epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	23846654	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	10809671	MGI
involved in insulin-like growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	12483226	MGI
acts upstream of or within positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	10809671	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	23846654	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
SHC-transforming protein 1	SH2 domain protein C1 SHC-transforming protein A

Shc1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Shc1	P98083	Grb2	Mus musculus	Q60631	Anti Bait CoIP	18273058
Intra	Shc1	P98083	Grb2	Mus musculus	Q60631	Anti Bait CoIP	11259577
Intra	Shc1	P98083	Grb2	Mus musculus	Q60631	CoIP	7529871
Intra	Shc1	P98083	Grb2	Mus musculus	Q60631	CoIP	10748054
Intra	Shc1	P98083	Ptpn12	Mus musculus	P35831	NMR	20075861
Intra	Shc1	P98083	Shcbp1	Mus musculus	Q9Z179	Y2H	15102471
Intra	Shc1	P98083	Amd1	Mus musculus	P0DMN7	Y2H	15102471
Intra	Shc1	P98083	Iqgap1	Mus musculus	Q9JKF1	Pull Down	20075861
Intra	Shc1	P98083	Iqgap1	Mus musculus	Q9JKF1	NMR	20075861

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS12856	SHC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21432	Shc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27950	Shc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Shc1	NCBI	NCBI:6464