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Grb2 - growth factor receptor bound protein 2 Gene

Also Known as Ash

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14784

Summary

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of Other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Three alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015]

Grb2 Products (3)

mRNA	Protein	Name
NM_001313936.1	NP_001300865.1	growth factor receptor-bound protein 2
NM_001313937.1	NP_001300866.1	growth factor receptor-bound protein 2
NM_008163.4	NP_032189.1	growth factor receptor-bound protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ephrin receptor binding	IPI IPI: Inferred from physical interaction	12925710	MGI
enables guanyl-nucleotide exchange factor adaptor activity	IDA IDA: Inferred from direct assay	8479536	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7518772	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	8438166	MGI
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	20398064	MGI
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	7689150	MGI
enables transmembrane receptor protein tyrosine kinase adaptor activity	IGI IGI: Inferred from genetic interaction	17881575	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in B cell receptor signaling pathway	IDA IDA: Inferred from direct assay	9199344	MGI
involved in Schwann cell development	IMP IMP: Inferred from mutant phenotype	10704452	MGI
acts upstream of or within anatomical structure formation involved in morphogenesis	IMP IMP: Inferred from mutant phenotype	11369229	MGI
acts upstream of or within branching involved in labyrinthine layer morphogenesis	IMP IMP: Inferred from mutant phenotype	11369229	MGI
acts upstream of or within endodermal cell differentiation	IMP IMP: Inferred from mutant phenotype	16908534	MGI
involved in epidermal growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	17881575	MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	11585837	MGI
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	8649419	MGI
involved in insulin-like growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	12483226	MGI
involved in myelination	IMP IMP: Inferred from mutant phenotype	10704452	MGI
acts upstream of or within positive regulation of actin filament polymerization	IGI IGI: Inferred from genetic interaction	17923684	MGI
acts upstream of or within regulation of MAPK cascade	IGI IGI: Inferred from genetic interaction	15569713	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	22561606	MGI
is active in cell cortex	IGI IGI: Inferred from genetic interaction	17881575	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	23793062	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15736129	MGI
located in membrane	IDA IDA: Inferred from direct assay	15983387	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17923684	MGI
located in vesicle membrane	IDA IDA: Inferred from direct assay	12147689	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
growth factor receptor-bound protein 2	SH2/SH3 adapter GRB2 adapter protein GRB2

Grb2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Grb2	Q60631	Dab2	Mus musculus	P98078	Anti Bait CoIP	9569023
Intra	Grb2	Q60631	Dab2	Mus musculus	P98078	Pull Down	9569023
Intra	Grb2	Q60631	Sos1	Mus musculus	Q62245	Anti Bait CoIP	9569023
Intra	Grb2	Q60631	Sos1	Mus musculus	Q62245	Pull Down	8479540
Intra	Grb2	Q60631	Sos1	Mus musculus	Q62245	Anti Tag CoIP	23452850
Intra	Grb2	Q60631	Snta1	Mus musculus	Q61234	SPR	11551227
Intra	Grb2	Q60631	Cd22	Mus musculus	P35329	CoIP	11551923
Intra	Grb2	Q60631	Cd22	Mus musculus	P35329	CoIP	10373493
Intra	Grb2	Q60631	Plcg1	Mus musculus	Q62077	Anti Bait CoIP	15953601
Intra	Grb2	Q60631	Shc1	Mus musculus	P98083	Anti Bait CoIP	17673906
Intra	Grb2	Q60631	Shc1	Mus musculus	P98083	Anti Tag CoIP	23452850
Intra	Grb2	Q60631	Shc1	Mus musculus	P98083	Anti Bait CoIP	7535773
Intra	Grb2	Q60631	Sos2	Mus musculus	Q02384	Anti Tag CoIP	23452850
Intra	Grb2	Q60631	Sos2	Mus musculus	Q02384	Anti Bait CoIP	15953601
Intra	Grb2	Q60631	Sos2	Mus musculus	Q02384	Y2H	15102471
Intra	Grb2	Q60631	Ptpn11	Mus musculus	P35235	Anti Tag CoIP	23452850
Intra	Grb2	Q60631	Khdrbs1	Mus musculus	Q60749	Pull Down	10077576
Intra	Grb2	Q60631	Khdrbs1	Mus musculus	Q60749	Y2H	15102471
Intra	Grb2	Q60631	Btk	Mus musculus	P35991	Y2H	15102471
Intra	Grb2	Q60631	Lat	Mus musculus	O54957	Crosslink	21487392
Intra	Grb2	Q60631	Blnk	Mus musculus	O54737	Y2H	15102471
Intra	Grb2	Q60631	Errfi1	Mus musculus	Q99JZ7	Y2H	15102471
Intra	Grb2	Q60631	Uck2	Mus musculus	Q99PM9	Y2H	15102471
Intra	Grb2	Q60631	Rapgef1	Mus musculus	Q91ZZ2	Y2H	15102471
Intra	Grb2	Q60631	Gab1	Mus musculus	Q9QYY0	Y2H	10871282
Intra	Grb2	Q60631	Gab1	Mus musculus	Q9QYY0	Y2H	15102471
Intra	Grb2	Q60631	Gab1	Mus musculus	Q9QYY0	Anti Bait CoIP	11445578
Intra	Grb2	Q60631	Gab1	Mus musculus	Q9QYY0	Anti Tag CoIP	23452850
Intra	Grb2	Q60631	Gab1	Mus musculus	Q9QYY0	Anti Tag CoIP	10871282
Intra	Grb2	Q60631	Ptpra	Mus musculus	P18052	Anti Tag CoIP	23452850
Intra	Grb2	Q60631	Ptpra	Mus musculus	P18052	Anti Bait CoIP	7518772
Intra	Grb2	Q60631	Ptpra	Mus musculus	P18052	Pull Down	7518772
Intra	Grb2	Q60631	Cblb	Mus musculus	B9EKI5	Y2H	15102471
Intra	Grb2	Q60631	Frs2	Mus musculus	Q8C180	Anti Tag CoIP	23452850
Intra	Grb2	Q60631	Frs2	Mus musculus	Q8C180	Pull Down	9182757
Intra	Grb2	Q60631	Tek	Mus musculus	Q02858	SPR	10521483
Intra	Grb2	Q60631	Tek	Mus musculus	Q02858	Pull Down	10521483
Intra	Grb2	Q60631	Prnp	Mus musculus	P04925	NMR	15301538
Intra	Grb2	Q60631	Prnp	Mus musculus	P04925	Fluorescence Spectr	15301538
Intra	Grb2	Q60631	Prnp	Mus musculus	P04925	CD	15301538

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N14349	Asterriquinone	Inhibitor	/	Phase 3
HY-153495	Prexigebersen		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153495A	Prexigebersen sodium	Inhibitor	98.95%	Unkown
HY-129800	CGP78850	Inhibitor	99.47%	Unkown
HY-146127A	Grb2 SH2 domain inhibitor 1 TFA	Inhibitor	99.62%	Unkown
HY-146127	Grb2 SH2 domain inhibitor 1	Inhibitor	98.24%	Unkown
HY-RS05780	GRB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17407	Grb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23861	Grb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grb2	NCBI	NCBI:2885