Frs2 - fibroblast growth factor receptor substrate 2 Gene

Also Known as SNT1; SNT-1; Frs2alpha; FRS2-alpha; C330018A15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 327826

Summary

Enables transmembrane receptor protein tyrosine kinase adaptor activity. Acts upstream of or within several processes, including animal organ development; organ induction; and regulation of MAPK cascade. Located in cell-cell junction; cytoplasm; and plasma membrane. Is expressed in several structures, including alimentary system; blastocyst; central nervous system; genitourinary system; and immune system. Orthologous to human FRS2 (Fibroblast Growth Factor receptor substrate 2). [provided by Alliance of Genome Resources, Apr 2022]

Frs2 Products (24)

mRNA Protein Name
NM_001408282.1 NP_001395211.1 fibroblast growth factor receptor substrate 2 isoform 1
NM_001408283.1 NP_001395212.1 fibroblast growth factor receptor substrate 2 isoform 1
NM_001408284.1 NP_001395213.1 fibroblast growth factor receptor substrate 2 isoform 1
NM_001408285.1 NP_001395214.1 fibroblast growth factor receptor substrate 2 isoform 1
NM_001408286.1 NP_001395215.1 fibroblast growth factor receptor substrate 2 isoform 1
NM_001408287.1 NP_001395216.1 fibroblast growth factor receptor substrate 2 isoform 1
NM_001408288.1 NP_001395217.1 fibroblast growth factor receptor substrate 2 isoform 1
NM_001408289.1 NP_001395218.1 fibroblast growth factor receptor substrate 2 isoform 1
NM_001408290.1 NP_001395219.1 fibroblast growth factor receptor substrate 2 isoform 1
NM_001408291.1 NP_001395220.1 fibroblast growth factor receptor substrate 2 isoform 1
NM_001408292.1 NP_001395221.1 fibroblast growth factor receptor substrate 2 isoform 1
NM_001408293.1 NP_001395222.1 fibroblast growth factor receptor substrate 2 isoform 1
NM_001408294.1 NP_001395223.1 fibroblast growth factor receptor substrate 2 isoform 1
NM_001408295.1 NP_001395224.1 fibroblast growth factor receptor substrate 2 isoform 1
NM_001408296.1 NP_001395225.1 fibroblast growth factor receptor substrate 2 isoform 1
NM_001408297.1 NP_001395226.1 fibroblast growth factor receptor substrate 2 isoform 1
NM_001408308.1 NP_001395237.1 fibroblast growth factor receptor substrate 2 isoform 2
NM_001408309.1 NP_001395238.1 fibroblast growth factor receptor substrate 2 isoform 2
NM_001408310.1 NP_001395239.1 fibroblast growth factor receptor substrate 2 isoform 2
NM_001408311.1 NP_001395240.1 fibroblast growth factor receptor substrate 2 isoform 2
NM_001408312.1 NP_001395241.1 fibroblast growth factor receptor substrate 2 isoform 2
NM_001408313.1 NP_001395242.1 fibroblast growth factor receptor substrate 2 isoform 2
NM_001408314.1 NP_001395243.1 fibroblast growth factor receptor substrate 2 isoform 2
NM_177798.4 NP_808466.1 fibroblast growth factor receptor substrate 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9182757 MGI
enables transmembrane receptor protein tyrosine kinase adaptor activity IDA
IDA: Inferred from direct assay
9182757 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterior/posterior axis specification, embryo IMP
IMP: Inferred from mutant phenotype
15870281 MGI
acts upstream of or within cell surface receptor protein tyrosine kinase signaling pathway IDA
IDA: Inferred from direct assay
9182757 MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
11585837 MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
23136392 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
16239343 MGI
acts upstream of or within gastrulation with mouth forming second IMP
IMP: Inferred from mutant phenotype
15870281 MGI
acts upstream of or within lens development in camera-type eye IMP
IMP: Inferred from mutant phenotype
23136392 MGI
acts upstream of or within lens fiber cell development IGI
IGI: Inferred from genetic interaction
23136392 MGI
acts upstream of or within lens fiber cell development IMP
IMP: Inferred from mutant phenotype
23136392 MGI
acts upstream of or within lens placode formation involved in camera-type eye formation IMP
IMP: Inferred from mutant phenotype
15569927 MGI
acts upstream of or within neuroblast proliferation IGI
IGI: Inferred from genetic interaction
16239343 MGI
acts upstream of or within neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
16239343 MGI
acts upstream of or within organ induction IMP
IMP: Inferred from mutant phenotype
15569927 MGI
acts upstream of or within positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
15569927 MGI
acts upstream of or within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IMP
IMP: Inferred from mutant phenotype
18184727 MGI
acts upstream of or within regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
23782834 MGI
acts upstream of or within regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
23782834 MGI
acts upstream of or within regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
18184727 MGI
acts upstream of or within ventricular septum development IMP
IMP: Inferred from mutant phenotype
17868091 MGI
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
23782834 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
9182757 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
9182757 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibroblast growth factor receptor substrate 2

  • FGFR substrate 2

  • FGFR-signaling adaptor SNT

  • suc1-associated neurotrophic factor target 1

Frs2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Frs2 Q8C180 Grb2 Mus musculus Q60631
Pull Down
9182757
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-165298 DGY-09-192 99.50% Unkown
HY-122888 MPT0L145 / Unkown
HY-158248 FGFR4-IN-19 Inhibitor / Unkown
HY-172916 LC-SF-14 Inhibitor / Unkown
HY-180794 LHQ766 Inhibitor / Unkown
HY-RS05112 FRS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22174 Frs2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28696 Frs2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Frs2 NCBI NCBI:10818