Iqgap1 - IQ motif containing GTPase activating protein 1 Gene

Also Known as mKIAA0051; D7Ertd237e; D7Ertd257e

Species: Mus musculus

Gene Type: protein coding

Gene ID: 29875

Summary

Enables small GTPase binding activity. Involved in cellular response to growth factor stimulus; positive regulation of protein kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Acts upstream of or within fibroblast migration; negative regulation of dephosphorylation; and regulation of cytokine production. Located in several cellular components, including cortical actin cytoskeleton; focal adhesion; and lateral plasma membrane. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and skin. Orthologous to human IQGAP1 (IQ motif containing GTPase activating protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Iqgap1 Products (1)

mRNA	Protein	Name
NM_016721.2	NP_057930.2	ras GTPase-activating-like protein IQGAP1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16628219	MGI
enables small GTPase binding	IPI IPI: Inferred from physical interaction	18604197	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in caveola assembly	IMP IMP: Inferred from mutant phenotype	20951348	MGI
involved in cellular response to epidermal growth factor stimulus	IMP IMP: Inferred from mutant phenotype	17563371	MGI
involved in cellular response to fibroblast growth factor stimulus	IMP IMP: Inferred from mutant phenotype	17563371	MGI
involved in cellular response to platelet-derived growth factor stimulus	IMP IMP: Inferred from mutant phenotype	17563371	MGI
involved in epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17563371	MGI
involved in fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17563371	MGI
acts upstream of or within fibroblast migration	IGI IGI: Inferred from genetic interaction	24841562	MGI
acts upstream of or within negative regulation of dephosphorylation	IGI IGI: Inferred from genetic interaction	21709260	MGI
involved in platelet-derived growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17563371	MGI
involved in positive regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	17563371	MGI
acts upstream of or within regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	21709260	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	35601831	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	35601831	MGI
located in cell leading edge	IDA IDA: Inferred from direct assay	24841562	MGI
located in cell leading edge	IGI IGI: Inferred from genetic interaction	16369480	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	18604197	MGI
located in cortical actin cytoskeleton	IPI IPI: Inferred from physical interaction	28089576	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	14516655	MGI
located in focal adhesion	IDA IDA: Inferred from direct assay	24841562	MGI
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	18604197	MGI
located in neuron projection	IGI IGI: Inferred from genetic interaction	16369480	MGI
located in nucleus	IDA IDA: Inferred from direct assay	20883816	MGI
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	21709260	MGI
part of ribonucleoprotein complex	IGI IGI: Inferred from genetic interaction	21709260	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ras GTPase-activating-like protein IQGAP1	Cdc42-Rac1 effector protein

Iqgap1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Iqgap1	Q9JKF1	Shc1	Mus musculus	P98083	Far-WB	20075861
Intra	Iqgap1	Q9JKF1	Shc1	Mus musculus	P98083	Pull Down	20075861
Cross	Iqgap1	Q9JKF1	gag	Moloney murine leukemia virus	P03332	Y2H	16628219
Cross	Iqgap1	Q9JKF1	gag	Moloney murine leukemia virus	P03332	Pull Down	16628219
Cross	Iqgap1	Q9JKF1	gag	Moloney murine leukemia virus	P03332	Anti Tag CoIP	16628219

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163707	UR778Br	Inducer	99.33%	Unkown
HY-RS06885	IQGAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20170	Iqgap1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26674	Iqgap1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Iqgap1	NCBI	NCBI:8826