MPRIP - myosin phosphatase Rho interacting protein Gene

Also Known as MRIP; RIP3; M-RIP; RHOIP3; p116Rip

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23164

About MPRIP

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:17,042,457-17,192,643 (from NCBI)

This gene has 21 transcripts (splice variants), 249 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 19.8), brain (RPKM 18.4) and 25 other tissues.

Summary

Enables Cadherin binding activity. Predicted to be involved in actin filament organization. Located in actin Cytoskeleton and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

MPRIP Products (3)

mRNA Protein Name
NM_001364716.4 NP_001351645.2 myosin phosphatase Rho-interacting protein isoform 3
NM_015134.4 NP_055949.2 myosin phosphatase Rho-interacting protein isoform 1
NM_201274.4 NP_958431.2 myosin phosphatase Rho-interacting protein isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15161933 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MPRIP Protein Structure

PH

PH: PH domain (46 - 145)

PH

PH: PH domain (390 - 481)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1025 a.a.
Protein Preferred Names Protein Names

myosin phosphatase Rho-interacting protein

  • Rho interacting protein 3

MPRIP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MPRIP Q6WCQ1 YWHAZ Homo sapiens P63104
Pull Down
15161933
Intra
MPRIP Q6WCQ1 YWHAQ Homo sapiens P27348
CoIP
15324660
Intra
MPRIP Q6WCQ1 YWHAQ Homo sapiens P27348
Y2H
21988832
Intra
MPRIP Q6WCQ1 SFN Homo sapiens P31947
TAP
15778465
Cross
MPRIP Q6WCQ1 Ppp1r12a Rattus norvegicus Q10728
Y2H
15545284
Cross
MPRIP Q6WCQ1 Ppp1r12a Rattus norvegicus Q10728
Anti Tag CoIP
15545284
Cross
MPRIP Q6WCQ1 Ppp1r12a Rattus norvegicus Q10728
Pull Down
15545284
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Congenital Mesoblastic Nephroma

  • Mesoblastic Nephroma

  • Nephroma, Mesoblastic
Cellular Congenital Mesoblastic Nephroma
Optic Atrophy 10 With Or Without Ataxia, Mental Retardation, And Seizures

  • OPA10

  • Optic Atrophy 10 With Or Without Ataxia, Intellectual Disability, And Seizures

  • Optic Atrophy 10

  • Atrophy, Optic, Type 10, With/Without Ataxia, Mental Retardation, And Seizures
Congenital Fibrosarcoma

  • Infantile Fibrosarcoma
Childhood Fibrosarcoma

  • Pediatric Fibrosarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-174330 TRK-IN-31 Inhibitor / Unkown
HY-174330A TRK-IN-31 hydrochloride Inhibitor / Unkown
HY-RS08629 MPRIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21654 Mprip Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28172 Mprip Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MPRIP VGNC VGNC:54331
Rattus norvegicus MPRIP RGD RGD:619947
Felis catus MPRIP VGNC VGNC:63576
Mus musculus MPRIP MGD MGI:1349438
Bos taurus MPRIP VGNC VGNC:57144
Macaca mulatta MPRIP VGNC VGNC:74867
Others MPRIP NCBI