SLN - sarcolipin Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6588

About SLN

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:107,707,378-107,712,056 (from NCBI)

This gene has 3 transcripts (splice variants) and 10 orthologues. Biased expression in heart (RPKM 82.3), esophagus (RPKM 53.1) and 2 other tissues.

Summary

Sarcoplasmic reticulum CA(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of CA(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum CA(2+)-ATPases. The transmembrane protein interacts with CA(2+)-ATPases and reduces the accumulation of CA(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008]

SLN Products (1)

mRNA Protein Name
NM_003063.3 NP_003054.1 sarcolipin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of ATPase-coupled calcium transmembrane transporter activity IDA
IDA: Inferred from direct assay
28890335 GOA
involved in regulation of ATPase-coupled calcium transmembrane transporter activity IDA
IDA: Inferred from direct assay
11781085 GOA
Cellular Component GO Annotation Evidence References Source
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
9575189 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLN Protein Structure

Sarcolipin

Sarcolipin: Sarcolipin (1 - 31)

  • 0
  • 31 a.a.
Protein Preferred Names Protein Names

sarcolipin

SLN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLN O00631 SYNE4 Homo sapiens Q8N205
Y2H Prey Pooling
25416956
Intra
SLN O00631 SYNE4 Homo sapiens Q8N205
Validated Y2H
25416956
Intra
SLN O00631 TMEM79 Homo sapiens Q9BSE2
Validated Y2H
25416956
Intra
SLN O00631 TMEM79 Homo sapiens Q9BSE2
Y2H Array
25416956
Intra
SLN O00631 TMEM79 Homo sapiens Q9BSE2
Y2H Prey Pooling
25416956
Intra
SLN O00631 TMEM79 Homo sapiens Q9BSE2
Y2H Array
31515488
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Brody Disease

  • Brody Myopathy

  • BROD

  • Sarcoplasmic Reticulum -Ca2+Atpase Deficiency

  • Myopathy, Brody
Myasthenic Syndrome, Congenital, 8

  • Congenital Myasthenic Syndrome 8

  • CMS8

  • Myasthenic Syndrome, Congenital, With Pre- And Postsynaptic Defects

  • Cmsppd

  • Myasthenic Syndrome, Congenital, 8, With Pre- And Postsynaptic Defects

  • Congenital Myasthenic Syndrome Due To Agrin Deficiency

  • Myasthenic Syndrome, Congenital, Due To Agrin Deficiency

  • Congenital Myasthenic Syndrome 8 With Pre- And Postsynaptic Defects

  • Myasthenic Syndrome, Congenital, Type 8, With Pre- And Postsynaptic Defects
Atrial Fibrillation

  • A-Fib

  • Fibrillation, Atrial

  • Af - [Atrial Fibrillation]

  • Rapid Atrial Fibrillation

  • A Fib - [Atrial Fibrillation]
Sciatic Neuropathy
Lesion Of Sciatic Nerve

  • Nerve Lesion Sciatic

  • Sciatic Neuropathy
Long Qt Syndrome

  • Romano-Ward Syndrome

  • Long Q-T Syndrome

  • Lqt

  • Qt Syndrome, Long

  • Congenital Long Qt Syndrome

  • Familial Long Qt Syndrome
Mononeuritis Of Lower Limb
Cardiomyopathy, Dilated, 1p

  • Dilated Cardiomyopathy 1p

  • CMD1P

  • Cardiomyopathy, Dilated 1p

  • Cardiomyopathy, Dilated, Type 1p
Hypertrophic Cardiomyopathy

  • Hypertrophic Obstructive Cardiomyopathy

  • Cardiomyopathy, Hypertrophic

  • Cardiomyopathy Hypertrophic Obstructive

  • Cardiomyopathy, Hypertrophic, Familial

  • Idiopathic Myocardial Hypertrophy

  • Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Cardiomyopathy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Muscular Subaortic Stenosis

  • Hypertrophic Obstructive Subaortic Stenosis
Malignant Hyperthermia

  • Anesthesia Related Hyperthermia

  • Malignant Hyperpyrexia Due To Anesthesia

  • Hyperpyrexia, Malignant

  • Hyperthermia, Malignant

  • Malignant Hyperpyrexia

  • Mhs

  • Malignant Fever
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명 효과
Purity Phase
HY-147278A Manusiran sodium Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-113217 Cholesteryl oleate 99.0% Unkown
HY-147425A Zerlasiran sodium Inhibitor 95.52% Unkown
HY-113217S Cholesteryl oleate-d7 ≥99.0% Unkown
HY-164390 6′SLN 99.87% Unkown
HY-W013122 Cholesteryl n-butyrate 99.75% Unkown
HY-147425 Zerlasiran Inhibitor 95.52% Unkown
HY-113217S1 Cholesteryl oleate-d7-1 / Unkown
HY-147278 Manusiran Inhibitor / Unkown
HY-147425C Zerlasiran sodium scrambled negative control / Unkown
HY-147425D FAM labled Zerlasiran sodium Inhibitor / Unkown
HY-147425E Cy3 labled Zerlasiran sodium Inhibitor / Unkown
HY-P11025 TMVP1446 / Unkown
HY-P11026 DOTA-TMVP1446 / Unkown
HY-RS13381 SLN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-123779 RWJ-49815 Inhibitor / Unkown
HY-168392 Propylene glycol monopalmitate / Unkown
HY-RS17627 Sln Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24087 Sln Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SLN RGD RGD:1305224
Mus musculus SLN MGD MGI:1913652
Others SLN NCBI