2. Epigenetics Metabolic Enzyme/Protease
  3. Small Interfering RNA (siRNA) Apolipoprotein
  4. Zerlasiran sodium

Zerlasiran (SLN360) sodium is a siRNA targeting apolipoprotein A (ApoA). Zerlasiran sodium targets hepatic ApoA synthesis via RNA interference to degrade encoding mRNA. Zerlasiran sodium can be used for the research of atherosclerotic cardiovascular disease and elevated ApoA levels.

For research use only. We do not sell to patients.

RNA, (Am-sp-(2′-deoxy-2′-fluoro)U-sp-Am-(2′-deoxy-2′-fluoro)A-Cm-(2′-deoxy-2′-fluoro)U-Cm-(2′-deoxy-2′-fluoro)U-Gm-(2′-deoxy-2′-fluoro)U-Cm-(2′-deoxy-2′-fluoro)C-Am-(2′-deoxy-2′-fluoro)U-Um-(2′-deoxy-2′-fluoro)A-Cm-sp-(2′-deoxy-2′-fluoro)C-sp-Gm), complex with RNA (Cm-Gm-Gm-Um-Am-Am-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)G-Am-Cm-Am-Gm-Am-Gm-Um-Um-sp-Am-sp-Um) 5′-[O-[21-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-9,9-bis[12-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-7-mercapto-7-oxido-2,6,8-trioxa-7-phosphadodec-1-yl]-16-mercapto-16-oxido-7,11,15,17-tetraoxa-16-phosphaheneicos-1-yl] hydroxy phosphate] (1:1), sodium salt

Zerlasiran sodium Chemical Structure

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Zerlasiran sodium Related Antibodies

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apoE apoB apoA1 apoA2 apoA4 apoC1 apoC2 apoC3

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Description

Zerlasiran (SLN360) sodium is a siRNA targeting apolipoprotein A (ApoA). Zerlasiran sodium targets hepatic ApoA synthesis via RNA interference to degrade encoding mRNA. Zerlasiran sodium can be used for the research of atherosclerotic cardiovascular disease and elevated ApoA levels[1][2].

In Vitro

Zerlasiran (300-600 mg) sodium reduces serum ApoA levels of up to 96-98%[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zerlasiran sodium Related Antibodies
Clinical Trial
Molecular Weight

14155.88 (free acid)

Formula

C443H556F12N144Na38O277P40S10
Appearance

Solid

Color

White to off-white

SMILES

[Zerlasiran (sodium)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 95.52%

SDS (252 KB)

COA (247 KB) RP-HPLC (208 KB) LCMS (576 KB)

Handling Instructions (2242 KB)
References
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Zerlasiran sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZerlasiranSLN360SLN 360SLN-360Small Interfering RNA (siRNA)ApolipoproteinApoAapolipoproteinInhibitorinhibitorinhibit

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