NUP93 - nucleoporin 93 Gene

Also Known as NIC96

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9688

About NUP93

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,730,129-56,850,286 (from NCBI)

This gene has 21 transcripts (splice variants), 216 orthologues and is associated with 2 phenotypes. Broad expression in testis (RPKM 20.8), thyroid (RPKM 10.6) and 24 other tissues.

Summary

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene encodes a nucleoporin protein that localizes both to the basket of the pore and to the nuclear entry of the central gated channel of the pore. The encoded protein is a target of Caspase cysteine proteases that play a central role in programmed cell death by Apoptosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

NUP93 Products (3)

mRNA Protein Name
NM_001242795.2 NP_001229724.1 nuclear pore complex protein Nup93 isoform 2
NM_001242796.2 NP_001229725.1 nuclear pore complex protein Nup93 isoform 2
NM_014669.5 NP_055484.3 nuclear pore complex protein Nup93 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26878725 GOA
enables structural constituent of nuclear pore IMP
IMP: Inferred from mutant phenotype
15229283 GOA
Biological Process GO Annotation Evidence References Source
involved in nuclear envelope organization IDA
IDA: Inferred from direct assay
26878725 GOA
involved in nuclear pore complex assembly IDA
IDA: Inferred from direct assay
26878725 GOA
involved in nuclear pore complex assembly IMP
IMP: Inferred from mutant phenotype
15229283 GOA
involved in positive regulation of SMAD protein signal transduction IDA
IDA: Inferred from direct assay
26878725 GOA
Cellular Component GO Annotation Evidence References Source
located in nuclear envelope IDA
IDA: Inferred from direct assay
24315095 GOA
located in nuclear membrane IDA
IDA: Inferred from direct assay
15229283 GOA
located in nuclear periphery IDA
IDA: Inferred from direct assay
15229283 GOA
part of nuclear pore IDA
IDA: Inferred from direct assay
12802065 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUP93 Protein Structure

Nic96

Nic96: Nup93/Nic96 (203 - 803)

  • 0
  • 200
  • 400
  • 600
  • 819 a.a.
Protein Preferred Names Protein Names

nuclear pore complex protein Nup93

  • 93 kDa nucleoporin

NUP93 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NUP93 Q8N1F7 TMEM100 Homo sapiens Q9NV29
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

NUP93 Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P810266 Nup93 Antibody (YA9610) WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA human, mouse, rat

Related Diseases

Diseases Alias
Nephrotic Syndrome, Type 12

  • NPHS12

  • Nephrotic Syndrome Type 12

  • Nephrotic Syndrome 12
Genetic Steroid-Resistant Nephrotic Syndrome

  • Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

  • Genetic Srns

  • Hereditary Steroid-Resistant Nephrotic Syndrome

  • Familial Idiopathic Nephrotic Syndrome

  • Nephrotic Syndrome, Steroid-Resistant, Autosomal Recessive

  • Srn1
Nephrotic Syndrome

  • Finnish Congenital Nephrotic Syndrome

  • Ns - [Nephrotic Syndrome]

  • Nephrosis Syndrome

  • Nephrosis Nos

  • Glomerular Lesion Nephrosis
Focal Segmental Glomerulosclerosis

  • Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

  • Focal Glomerulosclerosis

  • Fsgs

  • Segmental Glomerulosclerosis

  • Glomerulosclerosis, Focal Segmental

  • Fgs

  • Focal Glomerular Sclerosis

  • Familial Idiopathic Nephrotic Syndrome

  • Focal Sclerosis With Hyalinosis

  • Glomerulosclerosis, Focal

  • Glomerulosclerosis Focal

  • Glomerulosclerosis, Segmental, Focal

  • Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Breast Juvenile Papillomatosis

  • Juvenile Papillomatosis Of The Breast
Marcus Gunn Phenomenon

  • Jaw-Winking Syndrome

  • Marcus-Gunn Syndrome

  • Jaw-Winking

  • Maxillopalpebral Synkinesis

  • Abnormal Innervation Syndrome Of Eyelid

  • Jaw-Blinking

  • Pterygoid-Levator Synkinesis

  • Familial Marcus Gunn Phenomenon

  • Marcus Gunn Syndrome

  • Mandibulo-Palpebral Synkinesis-Ptosis Syndrome

  • Marcus-Gunn Phenomenon
Cranioectodermal Dysplasia 4

  • CED4

  • Sensenbrenner Syndrome 4

  • Dysplasia, Cranioectodermal, Type 4
Galloway-Mowat Syndrome

  • Galloway Mowat Syndrome

  • Galloway Syndrome

  • Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type

  • Microcephaly Nephrosis Syndrome

  • Microcephaly, Hiatal Hernia, And Nephrotic Syndrome

  • Nephrosis Neuronal Dysmigration Syndrome

  • Microcephaly-Hiatus Hernia-Nephrotic Syndrome

  • Nephrosis-Neuronal Dysmigration Syndrome
Frasier Syndrome

  • FS
Achalasia-Addisonianism-Alacrima Syndrome

  • Allgrove Syndrome

  • Triple-A Syndrome

  • Achalasia-Addisonianism-Alacrimia Syndrome

  • Alacrima-Achalasia-Adrenal Insufficiency Neurologic Disorder

  • Triple A Syndrome

  • Aaa Syndrome

  • AAAS

  • Glucocorticoid Deficiency With Achalasia

  • Glucocorticoid Deficiency And Achalasia

  • Addisonian-Achalasia Syndrome

  • Hypoadrenalism With Achalasia

  • Alacrima-Achalasia-Addisonianism

  • Aaa

  • Acth-Resistant Adrenal Insufficiency, Achalasia And Alacrima

  • Achalasia Addisonianism Alacrimia Syndrome

  • Achalasia Alacrima Syndrome

  • Addisonian Achalasia Syndrome

  • Achalasia-Addisonian Syndrome

  • Achalasia-Alacrima Syndrome

  • 2a Syndrome

  • 3a Syndrome

  • 4a Syndrome

  • Adrenal Insufficiency-Achalasia-Alacrima Syndrome

  • Double A Syndrome

  • Quaternary A Syndrome

  • Acth-Resistant Adrenal Insufficiency With Achalasia And Alacrima

  • Allgrove'S Syndrome

  • Adrenal Gland Hypofunction

  • Adrenal Cortical Hypofunction
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS09700 NUP93 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NUP93 RGD RGD:1311525
Mus musculus NUP93 MGD MGI:1919055
Bos taurus NUP93 VGNC VGNC:32366
Macaca mulatta NUP93 VGNC VGNC:75481
Felis catus NUP93 VGNC VGNC:63928
Canis familiaris NUP93 VGNC VGNC:44062
Others NUP93 NCBI