Methyl abietate
Methyl abietate is a methyl ester derivative of abietic acid, which can be extracted from the rosin of Pinus elliottii engelm. and Pinus massoniana Lamb. Methyl abietate can be produced via the esterification of abietic acid or abietic acid contained in rosin with methanol, and can also be prepared through hydrogenation to yield hydrogenated abietic acid methyl ester.
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- CAS No.: 127-25-3
- 화학식: C21H32O2
- 분자량:316.48
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
63.1 μM
Compound: 2
|
Cytotoxic activity against human A549 cells assessed as reduction in cell viability after 72 hrs by SRB assay
Cytotoxic activity against human A549 cells assessed as reduction in cell viability after 72 hrs by SRB assay
|
[PMID: 28011223] |
| HeLa | CC50 |
11 μM
Compound: 2
|
Cytotoxicity against human HeLa cells assessed as minimal toxic dosed detached 100% of the cell monolayer
Cytotoxicity against human HeLa cells assessed as minimal toxic dosed detached 100% of the cell monolayer
|
[PMID: 19892441] |
| HeLa | CC50 |
3.6 μg/mL
Compound: 2, methyl abietate
|
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
|
[PMID: 19217699] |
| PC-3 | IC50 |
79.32 μM
Compound: 2
|
Cytotoxic activity against human PC3 cells assessed as reduction in cell viability after 72 hrs by SRB assay
Cytotoxic activity against human PC3 cells assessed as reduction in cell viability after 72 hrs by SRB assay
|
[PMID: 28011223] |
| SK-OV-3 | IC50 |
81.31 μM
Compound: 2
|
Cytotoxic activity against human SKOV3 cells assessed as reduction in cell viability after 72 hrs by SRB assay
Cytotoxic activity against human SKOV3 cells assessed as reduction in cell viability after 72 hrs by SRB assay
|
[PMID: 28011223] |
| Vero | CC50 |
49.4 μg/mL
Compound: 2, methyl abietate
|
Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay
|
[PMID: 19217699] |
Methyl abietate (1.0 g; 120 d; 25-35°C) undergoes partial autoxidation at 25-35°C over 120 d, with 54.4% conversion, forming methyl dehydroabietate as the primary product plus unique products not observed in solvent-based high-temperature autoxidation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 127-25-3
-
분자량 316.48
-
화학식 C21H32O2
-
SMILES
C[C@@]12[C@](CC=C3[C@]2([H])CCC(C(C)C)=C3)([H])[C@@](C)(CCC1)C(OC)=O
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)