ZINC13407541
ZINC13407541 is a fibroblast growth factor 23 (FGF23) antagonist with an IC50 of 0.45 μM. ZINC13407541 preferentially binds to the FGF23:FGFR interface to disrupt their protein-protein interactions. ZINC13407541 can be used for the research of hypophosphatemia.
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- CAS No.: 864868-22-4
- 화학식: C14H15NO
- 분자량:213.28
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | EC50 |
1.41 10^3 μM
Compound: 1; ZINC13407541
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Cytotoxicity against HEK293T cells assessed as effect on LDH release measured after 5 hrs by CytoTox96 Non-Radioactive assay
Cytotoxicity against HEK293T cells assessed as effect on LDH release measured after 5 hrs by CytoTox96 Non-Radioactive assay
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[PMID: 33232874] |
ZINC13407541 acts as an FGF23 antagonist with an IC50 of 0.45 μM[1].
ZINC13407541 can bind to the non-FGFR-interacting distal pocket of FGF23Nterm, but also reveals it can bind to the predicted FGF23:FGFR protein-protein interaction region[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 864868-22-4
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분자량 213.28
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화학식 C14H15NO
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SMILES
O/N=C/C1=C(CCC1)/C=C/C2=CC=CC=C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ZINC13407541 Related Classifications
HY-183371 Related Classifications
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