2. Autophagy Membrane Transporter/Ion Channel
  3. Autophagy Sodium Channel
  4. Lamotrigine-d3

Lamotrigine-d3 is the deuterium labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al.

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Lamotrigine-d<sub>3</sub>

Lamotrigine-d3 Estructura química

No. CAS : 1132746-94-1

Tamaño Precio Stock Cantidad
1 mg Obtener un presupuesto 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
5 mg   Obtener un presupuesto  
10 mg   Obtener un presupuesto  
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Other Forms of Lamotrigine-d3:

Lamotrigine-d3 Related Antibodies

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Descripciòn

Lamotrigine-d3 is the deuterium labeled Lamotrigine[1]. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[2][3].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lamotrigine-d3 Related Antibodies
Peso molecular

259.11

Fòrmula

C9H4D3Cl2N5
No. CAS
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

NC1=NC(N)=C(C2=C(Cl)C(Cl)=C([2H])C([2H])=C2[2H])N=N1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : ≥ 10 mg/mL (38.59 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8594 mL 19.2968 mL 38.5937 mL
5 mM 0.7719 mL 3.8594 mL 7.7187 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8594 mL 19.2968 mL 38.5936 mL 96.4841 mL
5 mM 0.7719 mL 3.8594 mL 7.7187 mL 19.2968 mL
10 mM 0.3859 mL 1.9297 mL 3.8594 mL 9.6484 mL
15 mM 0.2573 mL 1.2865 mL 2.5729 mL 6.4323 mL
20 mM 0.1930 mL 0.9648 mL 1.9297 mL 4.8242 mL
25 mM 0.1544 mL 0.7719 mL 1.5437 mL 3.8594 mL
30 mM 0.1286 mL 0.6432 mL 1.2865 mL 3.2161 mL
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Lamotrigine-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lamotrigine-d31132746-94-1LTG-d3BW430C-d3AutophagySodium ChannelNa channelsNa+ channelsInhibitorinhibitorinhibit

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Nombre del producto:
Lamotrigine-d3
Cat. No.:
HY-B0495S5
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