Rufinamide-15N,d2
Rufinamide-15N,d2 (CGP 33101-15N,d2) is the deuterium and 15N labeled Rufinamide (HY-A0042).Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na+ current activation, inhibits neuronal hyperexcitability, and has anticonvulsant effects. Rufinamide is used in the study of Lennox-Gastaut syndrome.
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- CAS. Nr.: 1795037-48-7
- Formel: C10H6D2F2N315NO
- Molecular Weight:241.20
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-B0124S1
Zonisamide-13C2,15NStable Isotope -
HY-B0135S
Furosemide-d5Stable Isotope -
HY-W677042
α-AndrostenolGABAA Receptor PAM -
HY-B0448S
Phenytoin-d10Stable Isotope -
HY-145468
GPR52 antagonist-1GPR52 Antagonist -
HY-110234
Topiramate D12Antiepileptic Agent -
HY-141867
Z-FF-FMKCathepsin L Inhibitor -
HY-W010934S
3β,5α,6β-Trihydroxycholestane-d7Stable Isotope -
HY-B0351S
Taurine-d4Stable Isotope -
HY-W005749
(R)-4-Amino-3-hydroxybutyric acidGABAB Agonist -
HY-B0553S
Methazolamide-d6Stable Isotope -
HY-110234R
Topiramate D12 (Standard)Antiepileptic Agent
Biologische Aktivität
Beschreibung
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Anwendung
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 1795037-48-7
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Unlabeled CAS 106308-44-5
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Molecular Weight 241.20
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Formel C10H6D2F2N315NO
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SMILES
[15NH2]C(C(N=N1)=CN1C([2H])([2H])C2=C(C=CC=C2F)F)=O
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Synonyms
CGP 33101-15N,d2; E 2080-15N,d2; RUF 331-15N,d2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Chen JL, et.al. Inhibition of resurgent Na+ currents by rufinamide. Neuropharmacology. 2024 Apr 1;247:109835. [Content Brief]
[3]. White HS, et.al. The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. Epilepsia. 2008 Jul;49(7):1213-20. [Content Brief]
[4]. Suter MR, et.al. Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. Anesthesiology. 2013 Jan;118(1):160-72. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Rufinamide-15N,d2 Related Classifications
HY-A0042S1 Related Classifications
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