2. Anti-infection
  3. Fungal
  4. Ledol

Ledol ((+)-Ledol) is an antifungal agent isolated from the volatile oil components of Rhododendron tomentosum. Ledol also acts as an expectorant and antitussive, while it can cause adverse reactions such as dizziness, nausea and vomiting.

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Ledol

Ledol 構造式

CAS 番号 : 577-27-5

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in DMSO USD 33 在庫あり
Solid
10 mg $30 在庫あり
25 mg $55 在庫あり
50 mg $90 在庫あり
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Ledol 関連抗体

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  • 純度とドキュメンテーション

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製品説明

Ledol ((+)-Ledol) is an antifungal agent isolated from the volatile oil components of Rhododendron tomentosum. Ledol also acts as an expectorant and antitussive, while it can cause adverse reactions such as dizziness, nausea and vomiting[1].

Cellular Effect
Cell Line Type Value Description References
BV-2 IC50
>50 μM
Compound: 15
Antineuroinflammatory activity against mouse BV-2 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess assay
Antineuroinflammatory activity against mouse BV-2 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess assay
[PMID: 34978437]
体外実験

Ledol (1500 ng per band; 2 min at 100°C) is detectable as a dark blue band (Rf = 0.40) via qualitative HPTLC in essential oils from intact R. tomentosum plant material, but is absent in essential oils from R. tomentosum in vitro microshoot cultures[1].
Ledol (1500 ng per band; 30 min dark incubation) does not exhibit DPPH free radical scavenging activity under the tested conditions[1].
Ledol (1500 ng per band; 10 min fluorescent light exposure) does not exhibit superoxide scavenging activity under the tested conditions[1].
Ledol (1500 ng per band; 20 min at 38°C) does not exhibit xanthine oxidase inhibitory activity under the tested conditions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ledol 関連抗体
分子量

222.37

分子式

C15H26O
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O[C@@]1(C)CC[C@@]2([H])[C@@](C2(C)C)([H])[C@@]3([H])[C@@H](C)CC[C@@]13[H]
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMF : ≥ 50 mg/mL (224.85 mM)

DMSO : 12.5 mg/mL (56.21 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4970 mL 22.4850 mL 44.9701 mL
5 mM 0.8994 mL 4.4970 mL 8.9940 mL
10 mM 0.4497 mL 2.2485 mL 4.4970 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

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体積 （開始）

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In Vivo Dissolution Calculator
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純度とドキュメンテーション

純度: 98.0%

COA (262 KB) HNMR (250 KB) MS (69 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMF 1 mM 4.4970 mL 22.4850 mL 44.9701 mL 112.4252 mL
5 mM 0.8994 mL 4.4970 mL 8.9940 mL 22.4850 mL
10 mM 0.4497 mL 2.2485 mL 4.4970 mL 11.2425 mL
15 mM 0.2998 mL 1.4990 mL 2.9980 mL 7.4950 mL
20 mM 0.2249 mL 1.1243 mL 2.2485 mL 5.6213 mL
25 mM 0.1799 mL 0.8994 mL 1.7988 mL 4.4970 mL
30 mM 0.1499 mL 0.7495 mL 1.4990 mL 3.7475 mL
40 mM 0.1124 mL 0.5621 mL 1.1243 mL 2.8106 mL
50 mM 0.0899 mL 0.4497 mL 0.8994 mL 2.2485 mL
DMF 60 mM 0.0750 mL 0.3748 mL 0.7495 mL 1.8738 mL
80 mM 0.0562 mL 0.2811 mL 0.5621 mL 1.4053 mL
100 mM 0.0450 mL 0.2249 mL 0.4497 mL 1.1243 mL
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Ledol Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ledol577-27-5(+)-LedolFungalin vitro microshoot culturesessential oilHPTLCDPPH free radicalprostaglandin COXLedum palustresuperoxideRhododendron tomentosumxanthine oxidasearomadendrane skeleton sesquiterpenoidInhibitorinhibitorinhibit

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製品名:
Ledol
製品番号:
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