Lin28-let-7 antagonist 1

Cat. No.: HY-112659 Purity: 99.68%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Lin28-let-7 antagonist 1 (compound 1632) is a potent antagonist of Lin28/pre-let-7 interaction. Lin28-let-7 antagonist 1 inhibits Lin28A binding to pre-let-7a-2, with an IC₅₀ of 8 μM. Lin28-let-7 antagonist 1 inhibits proliferation in human cancer cells.

For research use only. We do not sell to patients.

Lin28-let-7 antagonist 1 Chemical Structure

CAS No. : 108825-65-6

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 94	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 94	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 85	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 135	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 285	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 460	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 735	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

Molecular Weight

281.31

Formula

C₁₅H₁₅N₅O

CAS No.

108825-65-6

Appearance

Solid

Color

Off-white to light yellow

SMILES

CN(C(C)=O)C1=CC=CC(C2=NN3C(C)=NN=C3C=C2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (177.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5548 mL	17.7740 mL	35.5480 mL
5 mM	0.7110 mL	3.5548 mL	7.1096 mL
10 mM	0.3555 mL	1.7774 mL	3.5548 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.68%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (247 KB) HNMR (116 KB) RP-HPLC (159 KB)

Handling Instructions (2659 KB)

References

[1]. Roos M, et al. A Small-Molecule Inhibitor of Lin28. ACS Chem Biol. 2016 Oct 21;11(10):2773-2781. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5548 mL	17.7740 mL	35.5480 mL	88.8699 mL
	5 mM	0.7110 mL	3.5548 mL	7.1096 mL	17.7740 mL
	10 mM	0.3555 mL	1.7774 mL	3.5548 mL	8.8870 mL
	15 mM	0.2370 mL	1.1849 mL	2.3699 mL	5.9247 mL
	20 mM	0.1777 mL	0.8887 mL	1.7774 mL	4.4435 mL
	25 mM	0.1422 mL	0.7110 mL	1.4219 mL	3.5548 mL
	30 mM	0.1185 mL	0.5925 mL	1.1849 mL	2.9623 mL
	40 mM	0.0889 mL	0.4443 mL	0.8887 mL	2.2217 mL
	50 mM	0.0711 mL	0.3555 mL	0.7110 mL	1.7774 mL
	60 mM	0.0592 mL	0.2962 mL	0.5925 mL	1.4812 mL
	80 mM	0.0444 mL	0.2222 mL	0.4443 mL	1.1109 mL
	100 mM	0.0355 mL	0.1777 mL	0.3555 mL	0.8887 mL