Leukotrienes

12-Oxo-leukotriene B4 (12-Oxo-LTB4) is an intermediate in the lipoxygenase-catalyzed path of Arachidonic acid (HY-109590) metabolism. 12-Oxo-leukotriene B4 is crucial in Leukotriene B4 metabolism and is involved in inflammation reactions. 12-Oxo-leukotriene B4 stimulates calcium levels in human neutrophils with an EC₅₀ of 33 nM. 12-Oxo-leukotriene B4 induces migration of neutrophils with EC₅₀ of 170 nM.

Leukotriene B3 is a LTA hydrolase metabolite of LTA3 in the leukotriene biosynthesis pathway. Leukotriene B3 has proinflammatory activity.

20-Hydroxy-leukotriene B4 is an endogenous metabolite present in Urine that can be used for the research of Sjogren Larsson Syndrome.

6-trans-12-epi-Leukotriene B4, an arachidonic acid metabolite, is a potent anti-inflammatory agent.

6-trans-leukotriene B4 is a neutrophil chemotaxin in the guinea pig dermis.

11-trans Leukotriene E4 is an isomer of Leukotriene E4 (LTE4). Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans Leukotriene E4 is equipotent to LTE4 in contracting guinea pig ileum.

Leukotriene F4 (LTF4), is a lipid that belongs to the Cysteinyl Leukotriene (CysTL) family. Leukotriene F4 induces bronchoconstriction with an ED₅₀ of 16 μg/kg. The precursor of LTF4 is Leukotriene E4 (LTE4), which isformed from the action of a glutamyl transferase.

Leukotriene E3 is a cysteinyl leukotriene metabolite derived from 5,8,11-eicosatrienoic acid (HY-108398A). Leukotriene E3 acts as a smooth-muscle-contracting mediator. Leukotriene E3 can be used for the research of allergic reactions and asthma.