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Cat. No.: HY-130497

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12-Oxo-leukotriene B4

(Synonyms: 12-Oxo-LTB4)

12-Oxo-leukotriene B4 (12-Oxo-LTB4) is an intermediate in the lipoxygenase-catalyzed path of Arachidonic acid (HY-109590) metabolism. 12-Oxo-leukotriene B4 is crucial in Leukotriene B4 metabolism and is involved in inflammation reactions. 12-Oxo-leukotriene B4 stimulates calcium levels in human neutrophils with an EC₅₀ of 33 nM. 12-Oxo-leukotriene B4 induces migration of neutrophils with EC₅₀ of 170 nM.

For research use only. We do not sell to patients.

CAS No.: 136696-10-1
Formula: C₂₀H₃₀O₄
Molecular Weight:334.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (261 KB)

12-Oxo-leukotriene B4 Chemical Structure

CAS No.: 136696-10-1

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Biological Activity

Description

12-Oxo-leukotriene B4 (12-Oxo-LTB4) is an intermediate in the lipoxygenase-catalyzed path of Arachidonic acid (HY-109590) metabolism. 12-Oxo-leukotriene B4 is crucial in Leukotriene B4 metabolism and is involved in inflammation reactions^[1]. 12-Oxo-leukotriene B4 stimulates calcium levels in human neutrophils with an EC₅₀ of 33 nM. 12-Oxo-leukotriene B4 induces migration of neutrophils with EC₅₀ of 170 nM^[2].

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Chemical Information

CAS No. 136696-10-1
Molecular Weight 334.45
Formula C₂₀H₃₀O₄
SMILES

CCCCC/C=C\CC(/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O)=O
Synonyms

12-Oxo-LTB4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Khanapure S P, et al., 12-Oxo-LTB4, a key pivotal intermediate in LTB4 metabolism[J]. The Journal of Organic Chemistry, 1995, 60(6): 1806-1813.

[2]. Powell WS, et al., Effects of metabolites of leukotriene B4 on human neutrophil migration and cytosolic calcium levels. J Pharmacol Exp Ther. 1996 Feb;276(2):728-36. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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12-Oxo-leukotriene B4

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

12-Oxo-leukotriene B4 Related Classifications

HY-130497 Related Classifications