2. Neuronal Signaling
  3. Monoamine Oxidase
  4. MAO-B-IN-5

MAO-B-IN-5 is a potent, selective and orally active MAO-B inhibitor with an IC50 of 0.204 µM. MAO-B-IN-5 has the potential for the research of Parkinson's disease (PD).

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MAO-B-IN-5

MAO-B-IN-5 Chemische Struktur

CAS. Nr. : 849909-77-9

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MAO-B-IN-5 Related Antibodies

Top Publications Citing Use of Products

Alle Monoamine Oxidase Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
MAO-A MAO-B

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Beschreibung

MAO-B-IN-5 is a potent, selective and orally active MAO-B inhibitor with an IC50 of 0.204 µM. MAO-B-IN-5 has the potential for the research of Parkinson's disease (PD)[1].

IC50 & Target

MAO-B

34.190 μM (IC50)

MAO-A

0.204 μM (IC50)

In Vitro

MAO-B-IN-5 (compound D0) (Sf9 cells) shows inhibitory activities towards MAO with the IC50s of 34.190 µM and 0.204 µM for MAO-A and MAO-B, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-B-IN-5 Related Antibodies
In Vivo

MAO-B-IN-5 (1 mg/kg, i.v.; 5 mg/kg, p.o.) shows oral bioavailability in rats (F=13.6%)[1].
Pharmacokinetic Parameters of MAO-B-IN-5 in SD rats[1].

Compound Route Dose (mg/kg) Cmax (ng/mL) AUCt (ng·h/mL) T1/2 (h) Vss (h) Cl (mL/min/kg) F (%)
D0 iv 1 809 347 0.37 1.11 47.1 /
po 5 163 284 1.27 / / 16.3
SD rats; 1 mg/kg, i.v.; 5 mg/kg, p.o.[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD rats[1]
Dosage: 1, 5 mg/kg
Administration: 1 mg/kg, i.v.; 5 mg/kg, p.o.
Result: Showed oral bioavailability in rats (F=16.3%).
Molekulargewicht

328.38

Formel

C19H21FN2O2
CAS. Nr.
SMILES

NC([C@@H]1CCCN1CC2=CC=C(C=C2)OCC3=CC(F)=CC=C3)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
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MAO-B-IN-5 Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-5849909-77-9Monoamine OxidaseMAOSafinamideParkinson's disease (PD)dopamineselectiveorally activeSD ratsSf9 cellsInhibitorinhibitorinhibit

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