MDM2/XIAP-IN-1
MDM2/XIAP-IN-1 (compound 14) is an orally active inhibitor of dual MDM2/XIAP. MDM2/XIAP-IN-1 has anti-cancer activity with an IC50 value of 0.3 μM, which can be used in cance rescrch.
For research use only. We do not sell to patients.
- CAS No.: 359595-95-2
- Formula: C28H28N2O4S
- Molecular Weight:488.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50:0.3 μM (EU-1 cell)[1]
MDM2/XIAP-IN-1 (0-4 μM, 48 h) inhibts the cell viability on two ALL cell lines (EU-1 and EU-3) and three NB cell lines (NB-1643, SHEP1, and LA1-55N)[1].
MDM2/XIAP-IN-1 degrades MDM2 and XIAP, killing tumor cells targeting, but not toxic to normal cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NB and normal human hematopoietic cells[1]
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Concentration:0-4 μM
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Incubation Time:2 weeks
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Result:Inhibited tumor cell growth, non-toxic to normal human hematopoietic cells.
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Cell Line:EU-1 cell[1]
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Concentration:0-2 μM
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Incubation Time:0-24 h
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Result:Caused the MDM2 and XIAP degradation as well as inducted p53 expression.
| Route | Dose (mg/kg) | AUClast (ng·h/mL) | t1/2 (h) | Clobs (L·h/kg) | F (%) |
| i.v. | 10 | 4750 | 0.94 | 2.12 | / |
| p.o. | 25 | 0.71 | / | / | 5.9% |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 359595-95-2
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Molecular Weight 488.60
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Formula C28H28N2O4S
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SMILES
O=C(OC)C1=CC=C(C2NC3=C(C=C(S(=O)(NC4=CC=C(C)C(C)=C4)=O)C=C3)C5C2CC=C5)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MDM2/XIAP-IN-1 Related Classifications
HY-153199 Related Classifications
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