Myosin I-IN-1
Myosin I-IN-1 is an Antifungal agent and Myosin I inhibitor with a Kd of 0.14 μM for FgMyoI. Myosin I-IN-1 inhibits mycelial growth, sporulation, spore germination, and Deoxynivalenol (HY-N6684) biosynthesis. Myosin I-IN-1 disrupts cell wall and cell membrane integrity and induces hyphal morphological changes. Myosin I-IN-1 exhibits broad-spectrum antifungal activity against plant pathogenic fungi. Myosin I-IN-1 shows protective efficacy against Fusarium head blight in wheat and maize. Myosin I-IN-1 can be used for research on Fusarium head blight.
For research use only. We do not sell to patients.
- Formula: C14H16FN3O2
- Molecular Weight:277.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Myosin I-IN-1 (Compound II-2) (0.2-1.0 mg/L; 2-4 days) shows potent in vitro antifungal activity against F. graminearum mycelial growth[1].
Myosin I-IN-1 (2.5 μM; 30 min) effectively inhibits the ATPase activity of FgMyoI[1].
Myosin I-IN-1 (0.0039-0.5 mg/L; 3 days) is a highly potent inhibitor of F. graminearum mycelial growth, with an EC50 of 0.0077 mg/L[1].
Myosin I-IN-1 (1.0 μM) inhibits the ATPase activity of wild-type FgMyoI, with mutations in the binding pocket reducing its inhibitory activity[1].
Myosin I-IN-1 (0.01-0.1 mg/L; 48 h) inhibits sporulation of F. graminearum[1].
Myosin I-IN-1 (0.04-0.4 mg/L; 6 h) effectively inhibits spore germination of F. graminearum[1].
Myosin I-IN-1 (0.01 mg/L; 7 days) reduces DON production in F. graminearum[1].
Myosin I-IN-1 (10.0 mg/L) exhibits broad-spectrum antifungal activity, particularly against Fusarium species[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Fusarium graminearum
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Concentration:0.2-1.0 mg/L
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Incubation Time:2-4 days
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Result:Exhibited a growth inhibition rate of 95.6% at 0.2 mg/L.
Exhibited a growth inhibition rate of 98.9% at 1.0 mg/L.
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Cell Line:Fusarium graminearum PH-1
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Concentration:0.0039-0.5 mg/L
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Incubation Time:3 days
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Result:Inhibited F. graminearum mycelial growth in a concentration-dependent manner with an EC50 value of 0.0077 mg/L.
In Vivo
Myosin I-IN-1 (80.0-200 mg a.i./L; dietary exposure via treated mulberry leaves) exhibits low acute toxicity to silkworms with an LC50 > 200 mg a.i./L[1].
Myosin I-IN-1 (dermal application) exhibits low acute dermal toxicity to mice with an LD50 > 5,000 mg/kg[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Danio rerio[1]
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Dosage:10.0 mg a.i./L
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Administration:aqueous exposure; 96 h
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Result:Showed minimal fatalities with an LC50 > 10.0 mg a.i./L.
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Animal Model:Bombyx mori[1]
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Dosage:80.0-200 mg a.i./L
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Administration:dietary exposure via treated mulberry leaves
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Result:No mortality was observed at up to 200 mg a.i./L, and the LC50 exceeded 200 mg a.i./L.
Chemical Information
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Molecular Weight 277.29
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Formula C14H16FN3O2
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SMILES
O=C(OCC)/C(C#N)=C(N)/C1=CC=C(NCC)C(F)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Myosin I-IN-1 Related Classifications
HY-189346 Related Classifications
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