Myosin light chain kinase fragment 11-19 amide
Myosin light chain kinase fragment 11-19 amide (MLCK(11-19) amide) is a substrate-specific peptide inhibitor of MLCK. Myosin light chain kinase fragment 11-19 amide inhibits hypotonicity-induced Ca2+ entry. Myosin light chain kinase fragment 11-19 amide can be used in the research of human cervical cancer.
For research use only. We do not sell to patients.
- CAS No.: 119386-39-9
- Formula: C40H78N18O11
- Molecular Weight:987.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
MLCK[1]
In Vitro
Myosin light chain kinase fragment 11-19 amide (5 μM) reduces the amplitude and rate of activation of noradrenaline-evoked non-selective cation current (Icat) in rabbit portal vein myocytes[1].
Myosin light chain kinase fragment 11-19 amide inhibits swelling-activated taurine transport with an IC50 value of 2.0 μM[2].
Myosin light chain kinase fragment 11-19 amide (10 μM) inhibits β2-integrin-mediated adhesion in neutrophils treated with KT5720 (25 μM)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 119386-39-9
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Molecular Weight 987.16
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Formula C40H78N18O11
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Synonyms
MLCK(11-19) amide
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Sequence Shortening
KKRAARATS-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Aromolaran AS, et al. Evidence for myosin light chain kinase mediating noradrenaline-evoked cation current in rabbit portal vein myocytes. J Physiol. 2000 May 1;524 Pt 3(Pt 3):853-63. [Content Brief]
[2]. Shen MR, et al. Myosin light chain kinase modulates hypotonicity-induced Ca2+ entry and Cl- channel activity in human cervical cancer cells. Pflugers Arch. 2002 May;444(1-2):276-85. [Content Brief]
[3]. Chilcoat CD, et al. Tonic protein kinase A activity maintains inactive beta2 integrins in unstimulated neutrophils by reducing myosin light-chain phosphorylation: role of myosin light-chain kinase and Rho kinase. J Leukoc Biol. 2008 Apr;83(4):964-71. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Myosin light chain kinase fragment 11-19 amide Related Classifications
HY-P3214 Related Classifications
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