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  3. PROTAC Linkers
  4. N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester)

N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) 

Art. -Nr.: HY-140095
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N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester)

N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) Chemische Struktur

CAS. Nr. : 2112732-01-9

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N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) Related Antibodies

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Beschreibung

N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) Related Antibodies
Molekulargewicht

519.58

Formel

C24H41NO11
CAS. Nr.
Appearance

Liquid (Density: 1.134 g/cm3)

Color

Colorless to light yellow

SMILES

C#CCOCCOCCOCCOCCC(N(CCOCCC(OC)=O)CCOCCC(OC)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Reinheit & Dokumentation
Verweise
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N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) Related Classifications

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Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester)2112732-01-9PROTAC LinkersInhibitorinhibitorinhibit

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N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester)
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