N6-(4-Methoxybenzyl)adenosine
N6-(4-Methoxybenzyl)adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
For research use only. We do not sell to patients.
- CAS No.: 23666-24-2
- Formula: C18H21N5O5
- Molecular Weight:387.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | IC50 |
19.5 μM
Compound: 16
|
Antitumor activity against mouse B16 cells after 72 hrs by Calcein AM assay
Antitumor activity against mouse B16 cells after 72 hrs by Calcein AM assay
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[PMID: 17418578] |
| CCRF-CEM | IC50 |
>166.7 μM
Compound: 16
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Antitumor activity against human CEM cells after 72 hrs by Calcein AM assay
Antitumor activity against human CEM cells after 72 hrs by Calcein AM assay
|
[PMID: 17418578] |
| G-361 | IC50 |
114.9 μM
Compound: 16
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Antitumor activity against human G361 cells after 72 hrs by Calcein AM assay
Antitumor activity against human G361 cells after 72 hrs by Calcein AM assay
|
[PMID: 17418578] |
| HL-60 | IC50 |
>166.7 μM
Compound: 16
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Antitumor activity against human HL60 cells after 72 hrs by Calcein AM assay
Antitumor activity against human HL60 cells after 72 hrs by Calcein AM assay
|
[PMID: 17418578] |
| HOS | IC50 |
>166.7 μM
Compound: 16
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Antitumor activity against human HOS cells after 72 hrs by Calcein AM assay
Antitumor activity against human HOS cells after 72 hrs by Calcein AM assay
|
[PMID: 17418578] |
| K562 | IC50 |
155.5 μM
Compound: 16
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Antitumor activity against human K562 cells after 72 hrs by Calcein AM assay
Antitumor activity against human K562 cells after 72 hrs by Calcein AM assay
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[PMID: 17418578] |
Chemical Information
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CAS No. 23666-24-2
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Molecular Weight 387.39
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Formula C18H21N5O5
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C(NCC4=CC=C(OC)C=C4)N=CN=C32)O[C@@H]1CO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. [Content Brief]
[2]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
N6-(4-Methoxybenzyl)adenosine Related Classifications
HY-152303 Related Classifications
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