2. Vitamin D Related/Nuclear Receptor MAPK/ERK Pathway
  3. p38 MAPK Progesterone Receptor
  4. Org OD 02-0

Org OD 02-0  (Synonyms: 10-Ethenyl-19-norprogesterone)

Cat. No.: HY-131547 Pureza: 99.7%
COA
SDS
Instrucciones de manejo Technical Support

Org OD 02-0 (10-Ethenyl-19-norprogesterone) is a membrane progesterone receptor α (mPRα)-specific agonist (IC50: 33.9 nM). Org OD 02-0 activates MAPK activity. Org OD 02-0 inhibits prolactin (PRL) secretion in the pituitary.

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Org OD 02-0

Org OD 02-0 Estructura química

No. CAS : 13258-85-0

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Org OD 02-0 Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas p38 MAPK:

Ver todas las isoformas
p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

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Descripciòn

Org OD 02-0 (10-Ethenyl-19-norprogesterone) is a membrane progesterone receptor α (mPRα)-specific agonist (IC50: 33.9 nM). Org OD 02-0 activates MAPK activity. Org OD 02-0 inhibits prolactin (PRL) secretion in the pituitary[1][2].

IC50 & Target

33.9 nM (mPRα)[1]
Peso molecular

326.47

Fòrmula

C22H30O2
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

CC([C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C=C)[C@@]3([H])CC[C@]12C)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 24 mg/mL (73.51 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 3.3 mg/mL (10.11 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0631 mL 15.3153 mL 30.6307 mL
5 mM 0.6126 mL 3.0631 mL 6.1261 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 99.7%

SDS (392 KB)

COA (253 KB) Elemental Analysis Report (112 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 3.0631 mL 15.3153 mL 30.6307 mL 76.5767 mL
5 mM 0.6126 mL 3.0631 mL 6.1261 mL 15.3153 mL
10 mM 0.3063 mL 1.5315 mL 3.0631 mL 7.6577 mL
DMSO 15 mM 0.2042 mL 1.0210 mL 2.0420 mL 5.1051 mL
20 mM 0.1532 mL 0.7658 mL 1.5315 mL 3.8288 mL
25 mM 0.1225 mL 0.6126 mL 1.2252 mL 3.0631 mL
30 mM 0.1021 mL 0.5105 mL 1.0210 mL 2.5526 mL
40 mM 0.0766 mL 0.3829 mL 0.7658 mL 1.9144 mL
50 mM 0.0613 mL 0.3063 mL 0.6126 mL 1.5315 mL
60 mM 0.0511 mL 0.2553 mL 0.5105 mL 1.2763 mL
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Org OD 02-0 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Org OD 02-013258-85-010-Ethenyl-19-norprogesteronep38 MAPKProgesterone ReceptorNR3C3PRLInhibitorinhibitorinhibit

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