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Cat. No.: HY-181193

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PROTAC SARS-CoV-2 Mpro degrader-7

PROTAC SARS-CoV-2 Mpro degrader-7 is a SARS-CoV-2 main protease (Mpro) PROTAC degrader with a DC₅₀ of 0.985 μM. PROTAC SARS-CoV-2 Mpro degrader-7 promotes K48-linked polyubiquitination of SARS-CoV-2 Mpro, leading to proteasome-dependent degradation via the ubiquitin-proteasome system.PROTAC SARS-CoV-2 Mpro degrader-7 forms a ternary complex with SARS-CoV-2 Mpro and CRBN E3 ubiquitin ligase to enable viral protease ubiquitination.PROTAC SARS-CoV-2 Mpro degrader-7 exhibits a high selectivity index, and induces dose-dependent degradation of SARS-CoV-2 Mpro in stable cells expressing the viral protease.PROTAC SARS-CoV-2 Mpro degrader-7 can be used for the research of COVID-19.

For research use only. We do not sell to patients.

Formula: C₃₅H₄₃N₅O₈
Molecular Weight:661.74

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

PROTAC SARS-CoV-2 Mpro degrader-7 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Cereblon

All PROTACs Isoforms :

In Vitro

PROTAC SARS-CoV-2 Mpro degrader-7 (PROTAC C) (0.0781-10 μM; 72 h) effectively induces dose-dependent degradation of SARS-CoV-2 Mpro in HEK293 stable cells with a DC₅₀ of 0.985 μM^[1].
PROTAC SARS-CoV-2 Mpro degrader-7 (72 h) has low cytotoxicity in HEK293 cells, with a CC₅₀ of 23.5 μM and a high selectivity index^[1].
PROTAC SARS-CoV-2 Mpro degrader-7 (2.5 μM; 72 h, co-treated with 2 μM MG-132 (HY-13259) for 18 h) induces Mpro degradation via the ubiquitin-proteasome system in HEK293 stable cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HEK293 stable cells expressing Flag-Mpro
Concentration:

0.0781 μM, 0.1563 μM, 0.3125 μM, 0.625 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM
Incubation Time:

72 h
Result:

Induced dose-dependent degradation of Mpro with a DC50 value of 0.985 μM and a maximum degradation rate of 79.4%.

Western Blot Analysis^[1]

Cell Line:

HEK293 stable cells expressing Flag-Mpro
Concentration:

2.5 μM (PROTAC); 2 μM MG-132 (proteasome inhibitor, co-treatment)
Incubation Time:

72 h (PROTAC); 18 h (MG132 co-treatment)
Result:

Enhanced K48-linked polyubiquitination of Mpro, and suppressed Mpro degradation when co-treated with MG-132.

Chemical Information

Molecular Weight 661.74
Formula C₃₅H₄₃N₅O₈
SMILES

COC([C@H](CC(C)C)NC([C@H](CC1=CC=CC=C1)NC(CCCCCNC2=C3C(N(C4CCC(NC4=O)=O)C(C3=CC=C2)=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Guo LN, et al. Integrated computational screen and validation of thalidomide-based PROTACs targeting SARS-CoV-2 main protease. RSC Med Chem. Published online January 13, 2026. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PROTAC SARS-CoV-2 Mpro degrader-7

All PROTACs Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC SARS-CoV-2 Mpro degrader-7 Related Classifications

HY-181193 Related Classifications