Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K

  • J Med Chem. 2004 Nov 18;47(24):5833-6. doi: 10.1021/jm0493111.
Eva Altmann  1 ,  Sandra W Cowan-Jacob ,  Martin Missbach
Affiliations
  • 1. Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland. [email protected]
PMID: 15537340 DOI: 10.1021/jm0493111
Abstract

Starting from the high-throughput screening hit 1a, novel Cathepsin K inhibitors have been developed based on a purine scaffold. High-resolution X-ray structures of several derivatives have revealed the binding mode of these unique cysteine Protease Inhibitors.

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