N,N'-Bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine stabilized a single pyrimidine bulge in duplex DNA

  • Bioorg Med Chem. 2005 Jul 15;13(14):4507-12. doi: 10.1016/j.bmc.2005.04.035.
Hitoshi Suda  1 ,  Akio Kobori ,  Jinhua Zhang ,  Gosuke Hayashi ,  Kazuhiko Nakatani
Affiliations
  • 1. Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Kyoto 615-8510, Japan.
PMID: 15916896 DOI: 10.1016/j.bmc.2005.04.035
Abstract

We here show the first identified ligand 2,7-diamino-1,8-naphthyridine (DANP) that strongly and specifically binds to the single cytosine and thymine bulges with exclusively 1:1 stoichiometry.

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