Human thioesterase superfamily member 2 (hTHEM2) is co-localized with beta-tubulin onto the microtubule

  • Biochem Biophys Res Commun. 2006 Dec 1;350(4):850-3. doi: 10.1016/j.bbrc.2006.09.105.
Zhongjun Cheng  1 ,  Shilai Bao ,  Xiaoyue Shan ,  Hang Xu ,  Weimin Gong
Affiliations
  • 1. School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, PR China.
PMID: 17045243 DOI: 10.1016/j.bbrc.2006.09.105
Abstract

Human thioesterase superfamily member 2 (hTHEM2) belongs to the hotdog-fold enzyme superfamily but its biological function remains unknown. Tissue specific expression in mouse showed that the encoding gene is highly expressed in the kidney, and moderately expressed in the liver, brain, large intestine, and small intestine. Small interference RNA silencing in cell line HCT116 shows that the hthem2 gene is essential for the cell sustained proliferation. Immunostaining and GFP-Tag experiments show that hTHEM2 is co-localized with microtubules.

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