Quinonoid and phenazine compounds: synthesis and evaluation against H37Rv, rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis

  • Eur J Med Chem. 2011 Sep;46(9):4521-9. doi: 10.1016/j.ejmech.2011.07.026.
Paula F Carneiro  1 ,  Maria do Carmo F R Pinto ,  Tatiane S Coelho ,  Bruno C Cavalcanti ,  Cláudia Pessoa ,  Carlos A de Simone ,  Isabelle K C Nunes ,  Nathalia M de Oliveira ,  Renata G de Almeida ,  Antonio V Pinto ,  Kelly C G de Moura ,  Pedro A da Silva ,  Eufrânio N da Silva Júnior
Affiliations
  • 1. Núcleo de Pesquisas de Produtos Naturais, UFRJ, 21941-971 Rio de Janeiro, Brazil.
PMID: 21820768 DOI: 10.1016/j.ejmech.2011.07.026
Abstract

Several quinonoid and phenazine compounds were synthesized in moderate to high yields and showed activity against H(37)Rv, rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis. The cytotoxity of the compounds were evaluated against human peripheral blood mononuclear cells (PBMC) and these substances emerge as promising antitubercular prototypes.