Cytotoxic Homoisoflavonoids from Ophiopogon japonicus Tubers

  • Chem Pharm Bull (Tokyo). 2017 Feb 1;65(2):204-207. doi: 10.1248/cpb.c16-00743.
Nguyen Hai Dang  1 ,  Nguyen Dinh Chung ,  Ha Manh Tuan ,  Nguyen Tuan Hiep ,  Nguyen Tien Dat
Affiliations
  • 1. Advanced Center for Bio-organic Chemistry, Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST).
PMID: 27916782 DOI: 10.1248/cpb.c16-00743
Abstract

A phytochemical fractionation of a methanol extract of Ophiopogon japonicus tubers led to the isolation of a new homoisoflavanone, homoisopogon A (1), and three new homoisoflavanes, homoisopogon B-D (2-4). Their chemical structures were elucidated by mass, NMR, and circular dichroism (CD) spectroscopic methods. Homoisopogon A (1) exhibited potent cytotoxicity against human lung adenocarcinoma LU-1, human epidermoid carcinoma KB, and human melanoma SK-Mel-2 Cancer cells with IC50 values ranging from 0.51 to 0.66 µM.

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