Combined Effects of M1 Muscarinic Acetylcholine Receptor Agonist TBPB and α7n-Acetylcholine Receptor Activator GTS-21 on Mouse Mortality and Blood Concentration of Proinflammatory Cytokines in Sepsis

  • Bull Exp Biol Med. 2017 Apr;162(6):750-753. doi: 10.1007/s10517-017-3704-3.
P F Zabrodskii  1 ,  M S Gromov  2 ,  V V Maslyakov  2
Affiliations
  • 1. Saratov Branch of Samara Medical Institute REAVIZ, Saratov, Russia. [email protected].
  • 2. Saratov Branch of Samara Medical Institute REAVIZ, Saratov, Russia.
PMID: 28429224 DOI: 10.1007/s10517-017-3704-3
Abstract

Experiments on random-bred albino mice showed that M1 Muscarinic Acetylcholine Receptor agonist (TBPB) and α7n-acetylcholine receptor agonist (GTS-21) significantly reduced mortality of mice with experimental sepsis (intraperitoneally administration of E. coli) in 4 and 24 h after modeling by reducing blood concentration of proinflammatory cytokines TNF-α, IL-1β, and IL-6. Combined treatment with TBPB and GTS-21 determined their additive effect.

Keywords
M1-acetylcholine receptors; cholinergic anti-inflammatory pathway; proinflammatory cytokines; sepsis; α7n-acetylcholine receptors.
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