New Dammarane-type Saponins from Gynostemma pentaphyllum

  • Molecules. 2019 Apr 8;24(7):1375. doi: 10.3390/molecules24071375.
Po-Yen Chen  1  2 ,  Chih-Chao Chang  3 ,  Hui-Chi Huang  4 ,  Li-Jie Zhang  5 ,  Chia-Ching Liaw  6 ,  Yu-Chi Lin  7 ,  Nham-Linh Nguyen  8  9 ,  Thanh-Hoa Vo  10  11 ,  Yung-Yi Cheng  12  13 ,  Susan L Morris-Natschke  14 ,  Kuo-Hsiung Lee  15  16 ,  Yao-Haur Kuo  17  18  19
Affiliations
  • 1. Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan. [email protected].
  • 2. Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan. [email protected].
  • 3. Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan. [email protected].
  • 4. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan. [email protected].
  • 5. Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan. [email protected].
  • 6. Department of Research and Development, Starsci Biotech Co. Ltd., Taipei 112, Taiwan. [email protected].
  • 7. Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan. [email protected].
  • 8. Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan. [email protected].
  • 9. The Ph.D. program in Clinical Drug Development of Chinese Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan. [email protected].
  • 10. Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan. [email protected].
  • 11. The Ph.D. program in Clinical Drug Development of Chinese Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan. [email protected].
  • 12. Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA. [email protected].
  • 13. Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 40402, Taiwan. [email protected].
  • 14. Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA. [email protected].
  • 15. Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA. [email protected].
  • 16. Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 40402, Taiwan. [email protected].
  • 17. Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei 112, Taiwan. [email protected].
  • 18. The Ph.D. program in Clinical Drug Development of Chinese Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan. [email protected].
  • 19. Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan. [email protected].
PMID: 30965662 DOI: 10.3390/molecules24071375
Abstract

Six new dammarane-type saponins, gypenosides CP1-6 (16), along with 19 known compounds 7⁻25, were isolated and characterized from the aerial parts of Gynostemma pentaphyllum. Among these compounds, eight dammarane-type saponins, 2, 5, 6, 7, 11, 12, 13, and 15, exhibited the greatest antiproliferative effects against two human tumor cell lines (A549 and HepG2).

Keywords
Gynostemma pentaphyllum; Jiaogulan; dammarane-type saponins; gypenosides antiproliferative activity.
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