Sarocladione, a unique 5,10:8,9-diseco-steroid from the deep-sea-derived fungus Sarocladium kiliense

  • Org Biomol Chem. 2019 Jun 18;17(24):5925-5928. doi: 10.1039/c9ob01159e.
Shao-Qiang Fan  1 ,  Chun-Lan Xie ,  Jin-Mei Xia ,  Cui-Ping Xing ,  Zhu-Hua Luo ,  Zongze Shao ,  Xiao-Jun Yan ,  Shan He ,  Xian-Wen Yang
Affiliations
  • 1. Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo 315211, China.
PMID: 31165123 DOI: 10.1039/c9ob01159e
Abstract

A novel ergostane, sarocladione (1), was isolated from the deep-sea-derived fungus Sarocladium kiliense, along with 20 known compounds. The structure of 1 was determined mainly by a detailed analysis of its experimental and calculated NMR spectroscopic data. It is worth noting that 1 was the first steroid bearing a 5,10:8,9-diseco moiety. All 21 compounds were tested for in vitro antitumor activities against five Cancer cell lines. β-Sitostenone (7) and 4,6-dihydroxyeudesmane (20) showed significant effects on HeLa-S3 cells with the IC50 values of 9.2 μM and 9.3 μM, respectively.

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