An ionizable lipid toolbox for RNA delivery

  • Nat Commun. 2021 Dec 13;12(1):7233. doi: 10.1038/s41467-021-27493-0.
Xuexiang Han  #  1 ,  Hanwen Zhang  #  1 ,  Kamila Butowska  1  2 ,  Kelsey L Swingle  1 ,  Mohamad-Gabriel Alameh  3 ,  Drew Weissman  3 ,  Michael J Mitchell  4  5  6  7  8
Affiliations
  • 1. Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • 2. Laboratory of Biophysics, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Abrahama 58, 80-307, Gdańsk, Poland.
  • 3. Department of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • 4. Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. [email protected].
  • 5. Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. [email protected].
  • 6. Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. [email protected].
  • 7. Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. [email protected].
  • 8. Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. [email protected].
  • # Contributed equally.
PMID: 34903741 DOI: 10.1038/s41467-021-27493-0
Abstract

Recent years have witnessed incredible growth in RNA therapeutics, which has benefited significantly from decades of research on Lipid Nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development.