Structures, biosynthesis and biological activities of benastatins, anthrabenzoxocinones and fredericamycins

  • Bioorg Chem. 2024 Sep:150:107572. doi: 10.1016/j.bioorg.2024.107572.
Bienvenu Tsakem  1 ,  Gang Li  2 ,  Rémy Bertrand Teponno  3
Affiliations
  • 1. Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
  • 2. China-Cameroon Joint Laboratory on Bioactive Natural Products from Endophytes, Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao 266071, People's Republic of China. Electronic address: [email protected].
  • 3. Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon. Electronic address: [email protected].
PMID: 38901281 DOI: 10.1016/j.bioorg.2024.107572
Abstract

The fast spread of Antibiotic resistance results in the requirement for a constant introduction of new candidates. Pentangular Polyphenols, a growing family of actinomycetes-derived aromatic type II polyketides, have attracted considerable attention due to their intriguing polycyclic systems and potent antimicrobial activity. Among them, benastatins, anthrabenzoxocinones (ABXs), and fredericamycins, display unique variations in their polycyclic frameworks, yet concurrently share structural commonalities within their substitutions. The present review summarizes advances in the isolation, spectroscopic characteristics, biosynthesis, and biological activities of pentangular Polyphenols benastatins (1-16), ABXs (17-39), and fredericamycins (40-42) from actinomycetes. The information presented here thus prompts researchers to further explore and discover additional congeners within these three small classes of pentangular Polyphenols.

Keywords
ABXs; Antibiotics; Benastatins; Fredericamycins; Pentangular polyphenols; Streptomyces.
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