(R)-Taltobulin (Synonyms: (R)-HTI-286; (R)-SPA-110)

Cat. No.: HY-15584C: Data Sheet Handling Instructions
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(R)-Taltobulin ((R)-HTI-286) can be used as a reference substance.

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(R)-Taltobulin 화학구조

CAS No. : 228266-44-2

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This product is a controlled substance and not for sale in your territory.

Other Forms of (R)-Taltobulin:

Taltobulin In-stock

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Biological Activity
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제품 설명

(R)-Taltobulin ((R)-HTI-286) can be used as a reference substance^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-15	IC₅₀	58 nM Compound: 41 (RSS isomer)	Inhibitory concentration against HCT-15 cells was evaluated Inhibitory concentration against HCT-15 cells was evaluated	[PMID: 15341492]
KB	IC₅₀	39 nM Compound: 41 (RSS isomer)	Concentration required to inhibit tumor cell growth in KB-8-5 cells Concentration required to inhibit tumor cell growth in KB-8-5 cells	[PMID: 15341492]
KB	IC₅₀	879 nM Compound: 41 (RSS isomer)	Concentration required to inhibit tumor cell growth in KB-V1 cells Concentration required to inhibit tumor cell growth in KB-V1 cells	[PMID: 15341492]
KB 3-1	IC₅₀	28 nM Compound: 41 (RSS isomer)	Concentration required to inhibit tumor cell growth in KB-3-1 cells Concentration required to inhibit tumor cell growth in KB-3-1 cells	[PMID: 15341492]
LOX IMVI	IC₅₀	37 nM Compound: 41 (RSS isomer)	Inhibitory concentration against Lox melanoma cells Inhibitory concentration against Lox melanoma cells	[PMID: 15341492]
MCF7	IC₅₀	10 nM Compound: 53, SPA123, Epi phenylhemiasterlin	Antimitotic activity against human MCF7 cells expressing p53 mutant by MTT assay Antimitotic activity against human MCF7 cells expressing p53 mutant by MTT assay	[PMID: 12608848]
MCF7	IC₅₀	25 nM Compound: 53, SPA123, Epi phenylhemiasterlin	Cytotoxicity activity against human MCF7 cells expressing p53 mutant by MTT assay Cytotoxicity activity against human MCF7 cells expressing p53 mutant by MTT assay	[PMID: 12608848]
NCI-H1299	IC₅₀	79 nM Compound: 41 (RSS isomer)	Inhibitory concentration against NCI-H1299 cells was evaluated Inhibitory concentration against NCI-H1299 cells was evaluated	[PMID: 15341492]

분자량

473.65

화학식

C₂₇H₄₃N₃O₄

CAS No.

228266-44-2

SMILES

CC(C)(C1=CC=CC=C1)[C@@H](NC)C(N[C@@H](C(C)(C)C)C(N(C)[C@@H](C(C)C)/C=C(C)/C(O)=O)=O)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Nieman JA, et al. Synthesis and antimitotic/cytotoxic activity of hemiasterlin analogues. J Nat Prod. 2003 Feb;66(2):183-99. [Content Brief]

(R)-Taltobulin Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Taltobulin228266-44-2(R)-HTI-286 (R)-SPA-110Drug IsomerMicrotubule/TubulinInhibitorinhibitorinhibit

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(R)-Taltobulin (Synonyms: (R)-HTI-286; (R)-SPA-110)

Other Forms of (R)-Taltobulin:

(R)-Taltobulin Related Antibodies

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•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

(R)-Taltobulin Related Classifications

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