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Cat. No.: HY-186081

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Ramiprilat acyl-β-D-glucuronide

Ramiprilat acyl-β-D-glucuronide is an acyl glucuronide metabolite of Ramiprilat (HY-B0279). Ramiprilat acyl-β-D-glucuronide undergoes methylation on its glucuronic acid moiety during solid phase extraction with strong cation exchanger cartridges, forming a methylated derivative. Ramiprilat acyl-β-D-glucuronide undergoes in-source conversion to Ramiprilat in mass spectrometry, with conversion extent proportional to declustering potential voltage.

For research use only. We do not sell to patients.

CAS No.: 1357570-22-9
Formula: C₂₇H₃₆N₂O₁₁
Molecular Weight:564.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Ramiprilat acyl-β-D-glucuronide Chemical Structure

CAS No.: 1357570-22-9

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

In Vitro

Ramiprilat acyl-β-D-glucuronide (10.00-100.00 μg/mL) is chromatographically separable from ramiprilat under initial reversed-phase HPLC conditions, does not cause ramiprilat quantification variability via in-source conversion, and undergoes a 65% loss with concurrent methylated derivative formation when processed using strong cation exchanger solid-phase extraction^[1].
Ramiprilat acyl-β-D-glucuronide (10.00-100.00 μg/mL) undergoes hydrolysis during evaporation in protein precipitation sample preparation, with reduced hydrolysis observed at an evaporation temperature of 35°C compared to 50°C^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1357570-22-9
Molecular Weight 564.58
Formula C₂₇H₃₆N₂O₁₁
SMILES

OC([C@H](CCC1=CC=CC=C1)N[C@@H](C)C(N2[C@]3([H])[C@](CCC3)([H])C[C@H]2C(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)C(O)=O)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Côté C, et al. Impact of methylation of acyl glucuronide metabolites on incurred sample reanalysis evaluation: ramiprilat case study. Bioanalysis. 2011;3(9):951-965. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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