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  2. Cytokines and Growth Factors Animal-free Recombinant Proteins
  3. Interferon & Receptors
  4. IFN-lambda
  5. IFN-lambda 1/IL-29
  6. Animal-Free IFN-lambda 1/IL-29 Protein, Human (His)

Animal-Free IFN-lambda 1/IL-29 Protein, Human (His)

Cat. No.: HY-P700121AF
COA Handling Instructions

IFN-lambda 1/IL-29 protein is a multifaceted cytokine with antiviral, antitumor, and immunomodulatory activities. It plays a crucial role in antiviral host defense, especially in epithelial tissues. Animal-Free IFN-lambda 1/IL-29 Protein, Human (His) is the recombinant human-derived animal-FreeIFN-lambda 1/IL-29 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IFN-lambda 1/IL-29 Protein, Human (His) is 178 a.a., with molecular weight of ~20.70 kDa.

Animal-free recombinant proteins offer high consistency and stability, whithout using or contacting of any animal-derived materials and reagents.

For research use only. We do not sell to patients.

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  • Biological Activity

  • Technical Parameters

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Description

IFN-lambda 1/IL-29 protein is a multifaceted cytokine with antiviral, antitumor, and immunomodulatory activities. It plays a crucial role in antiviral host defense, especially in epithelial tissues. Animal-Free IFN-lambda 1/IL-29 Protein, Human (His) is the recombinant human-derived animal-FreeIFN-lambda 1/IL-29 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IFN-lambda 1/IL-29 Protein, Human (His) is 178 a.a., with molecular weight of ~20.70 kDa.

Background

IFN-lambda 1/IL-29 Protein, a multifaceted cytokine, exhibits antiviral, antitumor, and immunomodulatory activities. It plays a crucial role in antiviral host defense, particularly in epithelial tissues. Functioning as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, receptor engagement triggers the activation of the JAK/STAT signaling pathway, leading to the expression of IFN-stimulated genes (ISG) that mediate the antiviral state. Notably, its receptor distribution is limited, predominantly active in epithelial cells due to the epithelial cell-specific expression of its receptor IFNLR1. This cell type-selective action contributes to its targeted efficacy. Additionally, IFN-lambda 1/IL-29 exerts an immunomodulatory effect by up-regulating MHC class I antigen expression, further enhancing its role in immune responses.

Biological Activity

Measure by its ability to induce IL-8 secretion in HuH7 cells. The ED50 for this effect is <6 ng/mL.

Species

Human

Source

E. coli

Tag

C-His

Accession

Q8IU54 (P23-T200)

Gene ID
Molecular Construction
N-term
IFN-λ1 (P23-T200)
Accession # Q8IU54
His
C-term
Synonyms
rHuIFN-λ1/IL-29; IL-29; IFN-lambda-1; Cytokine Zcyto21; Interleukin-29
AA Sequence

MPTSKPTTTGKGCHIGRFKSLSPQELASFKKARDALEESLKLKNWSCSSPVFPGNWDLRLLQVRERPVALEAELALTLKVLEAAAGPALEDVLDQPLHTLHHILSQLQACIQPQPTAGPRPRGRLHHWLHRLQEAPKKESAGCLEASVTFNLFRLLTRDLKYVADGNLCLRTSTHPEST

Molecular Weight

Approximately 20.70 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Appearance

Lyophilized powder.

Formulation

Lyophilized from a solution containing 1X PBS, pH 8.0.

Endotoxin Level

<0.1 EU per 1 μg of the protein by the LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

Animal-Free IFN-lambda 1/IL-29 Protein, Human (His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
Animal-Free IFN-lambda 1/IL-29 Protein, Human (His)
Cat. No.:
HY-P700121AF
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