IFNL1 - interferon lambda 1 Gene

Also Known as IL29; IL-29

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 282618

About IFNL1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,296,407-39,298,673 (from NCBI)

This gene has 1 transcript (splice variant), 140 orthologues and 2 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral Infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

IFNL1 Products (1)

mRNA	Protein	Name
NM_172140.2	NP_742152.1	interferon lambda-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables interleukin-28 receptor binding	IPI IPI: Inferred from physical interaction	12469119	GOA
enables signaling receptor binding	IDA IDA: Inferred from direct assay	12483210	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in defense response to virus	IDA IDA: Inferred from direct assay	12469119	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19346497	GOA
involved in negative regulation of T cell differentiation	IDA IDA: Inferred from direct assay	19346497	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15166220	GOA
involved in negative regulation of interleukin-13 production	IDA IDA: Inferred from direct assay	19346497	GOA
involved in negative regulation of interleukin-5 production	IDA IDA: Inferred from direct assay	19346497	GOA
involved in negative regulation of memory T cell differentiation	IDA IDA: Inferred from direct assay	19346497	GOA
involved in negative regulation of type 2 immune response	IDA IDA: Inferred from direct assay	19346497	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12483210	GOA
involved in positive regulation of MHC class I biosynthetic process	IDA IDA: Inferred from direct assay	12483210	GOA
involved in positive regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	12483210	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	19346497	GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	15166220	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in extracellular region	IDA IDA: Inferred from direct assay	12483210	GOA
part of interleukin-28 receptor complex	IDA IDA: Inferred from direct assay	12469119	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFNL1 Protein Structure

IL28A

0
100
200 a.a.

Protein Preferred Names	Protein Names
interferon lambda-1	IFN-lambda-1

Recombinant IFNL1 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P7026	IFN-lambda 1/IL-29 Protein, Human	Q8IU54 (G20-T200)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72551	IFN-lambda 1/IL-29 Protein, Human (HEK293, His)	Q8IU54 (G20-T200)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73202	IFN-lambda 1/IL-29 Protein, Human (HEK293)	Q8IU54 (G20-T200)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700121AF	Animal-Free IFN-lambda 1/IL-29 Protein, Human (His)	Q8IU54 (P23-T200)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Psoriasis 12	PSORS12 Psoriasis Susceptibility 12 Psoriasis 12, Susceptibility To
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Inflammatory Bowel Disease 23	IBD23

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS06591	IFNL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174660	Human IFNL1 mRNA		/	Unkown
HY-RS25695	Ifnl1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IFNL1	RGD	RGD:6493686
Others	IFNL1	NCBI