BACH2 Protein, Human (sf9, His, StrepⅡ)
BACH2 is a multifunctional transcriptional regulator that acts as both a repressor and an activator and recognizes Maf recognition elements (MAREs) to coordinate the transcriptional regulation of MAFKs. During oxidative stress, BACH2 induces apoptosis by inhibiting HMOX1. BACH2 Protein, Human (sf9, His, Strep) is the recombinant human-derived BACH2 protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
BACH2 is a multifunctional transcriptional regulator that acts as both a repressor and an activator and recognizes Maf recognition elements (MAREs) to coordinate the transcriptional regulation of MAFKs. During oxidative stress, BACH2 induces apoptosis by inhibiting HMOX1. BACH2 Protein, Human (sf9, His, Strep) is the recombinant human-derived BACH2 protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.
Background
BACH2, a versatile transcriptional regulator, exhibits dual roles as a repressor and activator. Recognizing Maf recognition elements (MARE), it coordinates transcriptional activation and repression in conjunction with MAFK. In response to oxidative stress, BACH2 induces apoptosis by repressing the antiapoptotic factor HMOX1. Moreover, it plays a pivotal role in adaptive immunity, critically contributing to the maintenance of regulatory T-cell function and B-cell maturation. BACH2 forms homodimers, disulfide-linked, and heterodimers with Maf-related transcription factors, emphasizing its involvement in complex regulatory networks. Additionally, BACH2 serves as a positive regulator of the nuclear import of actin, underscoring its diverse functions in cellular processes.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-StrepⅡ;N-8*His
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Accession
Q9BYV9 (S2-T841)
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Gene ID60468
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Molecular Construction
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N-term
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8*His-StrepⅡ
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BACH2 (S2-T841)
Accession # Q9BYV9 -
C-term
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Protein Length
Full Length
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Synonyms
BACH2; BTB And CNC Homology 1, Basic Leucine Zipper Transcription Factor 2; BACH Transcriptional Regulator 2; BTB Domain And CNC Homolog 2; Transcription Regulator Protein BACH2; BTB And CNC Homolog 2; BTBD25; IMD60
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AA Sequence
SVDEKPDSPMYVYESTVHCTNILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKNDLVVSLPEEVTARGFGPLLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQLLNSEDGLFVCRKDAACQRPHEDCENSAGEEEDEEEETMDSETAKMACPRDQMLPEPISFEAAAIPVAEKEEALLPEPDVPTDTKESSEKDALTQYPRYKKYQLACTKNVYNASSHSTSGFASTFREDNSSNSLKPGLARGQIKSEPPSEENEEESITLCLSGDEPDAKDRAGDVEMDRKQPSPAPTPTAPAGAACLERSRSVASPSCLRSLFSITKSVELSGLPSTSQQHFARSPACPFDKGITQGDLKTDYTPFTGNYGQPHVGQKEVSNFTMGSPLRGPGLEALCKQEGELDRRSVIFSSSACDQVSTSVHSYSGVSSLDKDLSEPVPKGLWVGAGQSLPSSQAYSHGGLMADHLPGRMRPNTSCPVPIKVCPRSPPLETRTRTSSSCSSYSYAEDGSGGSPCSLPLCEFSSSPCSQGARFLATEHQEPGLMGDGMYNQVRPQIKCEQSYGTNSSDESGSFSEADSESCPVQDRGQEVKLPFPVDQITDLPRNDFQMMIKMHKLTSEQLEFIHDVRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNQLKACMGELLDNFSCLSQEVCRDIQSPEQIQALHRYCPVLRPMDLPTASSINPAPLGAEQNIAASQCAVGENVPCCLEPGAAPPGPPWAPSNTSENCTSGRRLEGTDPGTFSERGPPLEPRSQTVTVDFCQEMTDKCTTDEQPRKDYT
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Purity
≥ 85%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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